Gene: Rheb
Official Full Name: Ras homolog enriched in brainprovided by MGI
Gene Summary: Enables GTP binding activity and protein kinase binding activity. Involved in negative regulation of cold-induced thermogenesis and positive regulation of TORC1 signaling. Acts upstream of or within positive regulation of oligodendrocyte differentiation. Part of spliceosomal complex. Is active in Golgi membrane and synapse. Is expressed in chondrocranium bone; nervous system; nucleus pulposus; and sensory organ. Orthologous to human RHEB (Ras homolog, mTORC1 binding). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01203 | Rheb Knockout cell line(RAW 264.7) | Mouse | Rheb | 1:2-1:3 | Negative | Online Inquiry |
Rheb Gene Knockout Cell Lines represent a groundbreaking advancement in molecular biology and genetic research, offering scientists a robust tool for elucidating the roles of the RHEB gene in cellular pathways. The RHEB gene encodes a GTPase that plays a critical role in the mTOR signaling pathway, which is integral for regulating cell growth, proliferation, and metabolism. By providing knockout versions of these cell lines, researchers can effectively silence RHEB function, allowing for detailed study of its downstream effects and elucidation of associated signaling cascades.
These cell lines function by utilizing CRISPR-Cas9 technology for precise gene editing, resulting in the complete removal of the RHEB gene and its associated transcripts. This gene knockout facilitates the observation of phenotypic outcomes in vitro, enabling a better understanding of RHEB's involvement in various physiological and pathological processes, including cancer, metabolic disorders, and neurodegeneration. As a result, they serve as valuable models for drug screening, biomarker discovery, and therapeutic interventions.
The scientific importance of Rheb Gene Knockout Cell Lines is underscored by their potential applications in both research and clinical settings. By utilizing these cell lines, scientists can investigate the complexities of mTOR pathway regulation, develop targeted therapeutics for hyperactive mTOR signaling, and unravel the underlying mechanisms of disease states linked to RHEB dysregulation.
What sets this product apart from alternatives is its precise gene editing capabilities, convenience of use, and adaptability to various experimental designs. Unlike traditional loss-of-function approaches, our Rheb Gene Knockout Cell Lines are designed for reproducibility and robustness, thereby ensuring that researchers can achieve high-quality, interpretable data.
In addition to these scientific merits, the Rheb Gene Knockout Cell Lines provide significant value to researchers and clinicians alike by streamlining experimental workflows and supporting a wide range of applications from basic research to translational medicine.
At [Your Company Name], we pride ourselves on our commitment to excellence in developing biological tools that empower researchers and drive innovation within the biomedical field. Our expertise ensures that every product we offer is backed by rigorous scientific validation, providing our customers with the confidence to advance their research effectively.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.