Gene: Recql5
Official Full Name: RecQ protein-like 5provided by MGI
Gene Summary: Predicted to enable DNA helicase activity; RNA polymerase II complex binding activity; and identical protein binding activity. Acts upstream of or within several processes, including cellular response to camptothecin; negative regulation of double-strand break repair via homologous recombination; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription preinitiation complex. Predicted to be active in cytoplasm; nucleus; and replication fork. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00019 | Recql5 gRNA3-gRNA4 KO plasmid | Recql5 | $850 | |||
GP00247 | Recql5 gRNA1-gRNA2 KO plasmid | Recql5 | $850 | |||
KO01149 | Recql5 Knockout cell line(C2C12) | Mouse | Recql5 | 1:3~1:4 | Negative | Online Inquiry |
Recql5 Gene Knockout Cell Lines are specifically engineered cellular models created to facilitate the in-depth study of the Recql5 gene's function and its role in cellular processes such as DNA repair, replication, and genomic stability. These cell lines are generated using the CRISPR-Cas9 gene-editing technology, which enables precise modifications in the genome, ensuring complete knockout of the Recql5 gene.
The key mechanism underlying the utility of Recql5 knockout cell lines lies in their ability to mimic the physiological conditions of Recql5-deficient organisms, thereby providing researchers with a valuable tool to examine the consequences of Recql5 loss. These model systems can elucidate pathways involved in DNA repair mechanisms and explore the gene's significance in tumorigenesis, response to DNA damage, and cellular response to anticancer therapies.
Scientifically, Recql5 has been implicated in essential biological processes, and its dysregulation is associated with various malignancies. Consequently, these knockout cell lines have numerous applications in both research and clinical settings, such as drug screening, studying therapeutic targets, and understanding the molecular underpinnings of diseases linked to Recql5 dysfunction.
One of the primary advantages of using our Recql5 Gene Knockout Cell Lines is their reliability and reproducibility, which are essential characteristics in experimental design. Compared to traditional gene knockout methods, CRISPR technology offers enhanced efficiency and specificity, reducing off-target effects and alignment with the latest research requirements. Additionally, these cell lines come with comprehensive validation data that support their robustness and utility, further distinguishing our product in the marketplace.
For researchers, clinicians, and pharmaceutical companies, Recql5 Gene Knockout Cell Lines represent an invaluable resource to accelerate discovery and translate findings into clinical applications. By leveraging our proven expertise in cell line development and cutting-edge gene-editing technologies, we are committed to supporting breakthroughs in biological research and therapeutic innovation across various disciplines.
Please note that all services are for research use only. Not intended for any clinical use.
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