Gene: RYK
Official Full Name: receptor like tyrosine kinaseprovided by HGNC
Gene Summary: The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11677 | RYK Knockout cell line (HeLa) | Human | RYK | 1:3~1:6 | Negative | Online Inquiry |
KO11678 | RYK Knockout cell line (HCT 116) | Human | RYK | 1:2~1:4 | Negative | Online Inquiry |
KO11679 | RYK Knockout cell line (HEK293) | Human | RYK | 1:3~1:6 | Negative | Online Inquiry |
KO11680 | RYK Knockout cell line (A549) | Human | RYK | 1:3~1:4 | Negative | Online Inquiry |
RYK Gene Knockout Cell Lines are advanced genetically modified cellular models designed to facilitate the study of the RYK gene, a critical component in various biological processes, including cell signaling and developmental pathways. These cell lines are produced using state-of-the-art CRISPR/Cas9 technology, which enables the precise deletion of the RYK gene, allowing researchers to investigate its functional implications in various physiological and pathological contexts.
The primary function of RYK Gene Knockout Cell Lines is to provide a controlled environment where researchers can assess the consequences of RYK gene inactivation on cellular behavior, signaling cascades, and overall cellular homeostasis. By eliminating this specific gene, scientists can explore its role in cancers, neurological disorders, and developmental anomalies.
Scientifically, these knockout cell lines are invaluable in both research and clinical settings. They serve as robust platforms for drug discovery and toxicity testing, enabling the identification of novel therapeutic targets and enhancing the understanding of disease mechanisms. Their application extends to elucidating gene functions in signal transduction pathways, providing insights that can lead to breakthroughs in personalized medicine.
The RYK Gene Knockout Cell Lines present compelling advantages over conventional models. Their precise genetic modification ensures reproducibility and specificity in experimental outcomes. Furthermore, compared to other gene-editing methodologies, CRISPR/Cas9 provides higher efficiency and lower off-target effects, making these cell lines a superior choice for rigorous scientific inquiry.
Researchers and clinicians will find significant value in utilizing RYK Gene Knockout Cell Lines as they offer a streamlined approach to gene function analysis and drug development, ultimately paving the way for innovative therapeutic strategies. Our company stands at the forefront of genetic engineering, committed to delivering high-quality biological products backed by extensive expertise and a focus on advancing scientific research.
Please note that all services are for research use only. Not intended for any clinical use.
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