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RXRA Knockout Cell Lines

Gene: RXRA

Official Full Name: retinoid X receptor alphaprovided by HGNC

Gene Summary: Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00367 RXRA Knockout cell line(5637) Human RXRA 1:2-1:3 Negative Online Inquiry
KO10152 RXRA Knockout cell line (HeLa) Human RXRA 1:3~1:6 Negative Online Inquiry
KO10153 RXRA Knockout cell line (HCT 116) Human RXRA 1:2~1:4 Negative Online Inquiry
KO10154 RXRA Knockout cell line (HEK293) Human RXRA 1:3~1:6 Negative Online Inquiry
KO10155 RXRA Knockout cell line (A549) Human RXRA 1:3~1:4 Negative Online Inquiry

Background

RXRA Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology aimed at advancing our understanding of gene functions and related pathways. These cell lines are specifically engineered to disrupt the RXRA gene, which codes for the retinoid X receptor alpha—a vital transcription factor involved in numerous physiological processes such as metabolism, cellular differentiation, and immune response. By creating a knockout of the RXRA gene, these cell lines allow researchers to study the functional consequences of gene loss, providing insights into RXRA-mediated signaling pathways.

The mechanism behind the functionality of RXRA Gene Knockout Cell Lines lies in CRISPR/Cas9 gene-editing technology, which precisely targets and inactivates the RXRA gene. This innovative approach enables researchers to create models that mimic certain disease states or phenotypic variations, thereby facilitating a deeper exploration of RXRA's role in various biological contexts. Such cell lines are invaluable in elucidating the interplay between RXRA and metabolic syndromes, cancer, and genetic disorders.

In both research and clinical settings, RXRA Gene Knockout Cell Lines serve as pivotal tools for drug discovery and disease modeling. Their applications extend to potential therapeutic interventions where modulation of RXRA activity may provide new avenues for treatment. The specificity and reproducibility of these knockout cell lines offer significant advantages over traditional models, providing consistency in experimental results and increased confidence in data interpretation.

Compared to alternative approaches, such as transient gene silencing methods, RXRA Gene Knockout Cell Lines deliver a stable and permanent genetic alteration, permitting long-term studies of gene function without the variability often associated with transient knockdowns. This stability is crucial for reducing experimental noise and facilitating robust data collection.

For researchers and clinicians focused on gene regulation, cellular signaling, and metabolic diseases, RXRA Gene Knockout Cell Lines present an invaluable model that can significantly enhance the efficacy and reliability of experimental outcomes. With a strong foundation in molecular genetics and cell biology, our company is committed to providing high-quality, meticulously validated biological products that empower scientific discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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