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RUNX1T1 Knockout Cell Lines

Gene: RUNX1T1

Official Full Name: RUNX1 partner transcriptional co-repressor 1provided by HGNC

Gene Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03617 RUNX1T1 Knockout cell line (HEK293) Human RUNX1T1 1:3~1:6 Negative Online Inquiry

Background

RUNX1T1 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate research into the functional genomics of the RUNX1T1 gene, a crucial component involved in hematopoiesis and various leukemias. These knockout cell lines are proficiently created using advanced CRISPR/Cas9 technology, rendering them invaluable for studying the gene's role in cellular processes such as differentiation, proliferation, and apoptosis.

The primary mechanism of these knockout cell lines involves the targeted disruption of the RUNX1T1 gene, leading to a loss of its associated protein product. This allows researchers to observe the resultant phenotypic and molecular changes, enabling a comprehensive understanding of RUNX1T1's involvement in normal and malignant cell behavior. Consequently, these cell lines are pivotal for elucidating the mechanisms underpinning diseases like acute myeloid leukemia (AML) and other hematological disorders.

In the realm of scientific research and clinical settings, RUNX1T1 Gene Knockout Cell Lines serve as essential tools for drug discovery and development, biomarker identification, and functional studies of gene interactions. They provide a consistent and reproducible model for translating laboratory findings into therapeutic strategies, addressing the significant challenge of cancer treatment modalities.

What distinguishes these cell lines from alternative models is their high fidelity in replicating the human cellular environment, as well as the robustness of data generated through their use. Researchers can expect reduced variability and increased reliability in experimental outcomes, enhancing the overall efficiency of their studies.

Investing in RUNX1T1 Gene Knockout Cell Lines is a vital step for any researcher or clinician aiming to delve into the complexities of hematological diseases and potential therapeutic interventions. Our commitment to providing expertly curated biological products stems from years of experience in the field, ensuring that researchers receive the highest quality resources for their innovative projects.

Please note that all services are for research use only. Not intended for any clinical use.

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