Gene: RUFY1
Official Full Name: RUN and FYVE domain containing 1provided by HGNC
Gene Summary: This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26087 | RUFY1 Knockout cell line (HeLa) | Human | RUFY1 | 1:3~1:6 | Negative | Online Inquiry |
KO26088 | RUFY1 Knockout cell line (HCT 116) | Human | RUFY1 | 1:2~1:4 | Negative | Online Inquiry |
KO26089 | RUFY1 Knockout cell line (HEK293) | Human | RUFY1 | 1:3~1:6 | Negative | Online Inquiry |
KO26090 | RUFY1 Knockout cell line (A549) | Human | RUFY1 | 1:3~1:4 | Negative | Online Inquiry |
RUFY1 Gene Knockout Cell Lines are specifically engineered cellular models that provide researchers with a powerful tool for studying the biological functions and pathways associated with the RUFY1 gene. This gene encodes a protein involved in various cellular processes, including cell signaling, cytoskeletal organization, and immune response regulation. By creating knockout cell lines that lack RUFY1 expression, scientists can elucidate the gene's role in health and disease, allowing for a deeper understanding of its contribution to cellular physiology.
The creation of RUFY1 Gene Knockout Cell Lines utilizes advanced CRISPR-Cas9 gene-editing technology, which enables precise modification of the genome. This mechanism allows for the targeted disruption of the RUFY1 gene, resulting in a complete loss of function. Researchers can then assess the resulting phenotypic changes, providing insights into the biological pathways that RUFY1 influences. Such investigations are crucial not only for basic biology but also for therapeutic development, especially in fields such as immunology and oncology.
From a scientific perspective, RUFY1 Gene Knockout Cell Lines are invaluable in elucidating the molecular mechanisms underpinning diseases associated with RUFY1 dysregulation. Their applications span fundamental research aimed at understanding gene function, drug discovery, and the investigation of disease mechanisms. Moreover, these cell lines serve as critical tools for preclinical studies, enabling the evaluation of therapeutic candidates targeting pathways influenced by RUFY1.
Compared to alternative models, RUFY1 Gene Knockout Cell Lines provide unparalleled precision and specificity. Unlike traditional methods of gene silencing, such as RNA interference, knockout models allow for the complete elimination of gene function, offering a clearer understanding of gene-associated phenotypes. This specificity is essential for researchers seeking reliable data in translational research.
Researchers and clinicians alike will find RUFY1 Gene Knockout Cell Lines to be a highly valuable addition to their toolkit. By enabling a comprehensive investigation of gene function and its implications in various biological contexts, these knockout models can accelerate discoveries that lead to novel therapeutic strategies.
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