Gene: RSPH3
Official Full Name: radial spoke head 3provided by HGNC
Gene Summary: The protein encoded by this gene acts as a protein kinase A anchoring protein. Mutations in this gene cause primary ciliary dyskinesia; a disorder characterized by defects of the axoneme in motile cilia and sperm flagella. The homolog of this gene was first identified in the blue-green algae Chlamydomonas as encoding a radial spoke protein that formed a structural component of motile cilia and flagella. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25348 | RSPH3 Knockout cell line (HeLa) | Human | RSPH3 | 1:3~1:6 | Negative | Online Inquiry |
KO25349 | RSPH3 Knockout cell line (HCT 116) | Human | RSPH3 | 1:2~1:4 | Negative | Online Inquiry |
KO25350 | RSPH3 Knockout cell line (HEK293) | Human | RSPH3 | 1:3~1:6 | Negative | Online Inquiry |
KO25351 | RSPH3 Knockout cell line (A549) | Human | RSPH3 | 1:3~1:4 | Negative | Online Inquiry |
RSPH3 Gene Knockout Cell Lines are genetically modified cellular models specifically engineered to lack the RSPH3 gene, which plays a critical role in ciliary structure and function. This innovative product enables researchers to investigate the biological implications of RSPH3 deficiency and its contribution to various pathophysiological conditions, including ciliopathies.
The key function of RSPH3 Gene Knockout Cell Lines is to provide a platform for studying the mechanisms of ciliary dysregulation. By excising the RSPH3 gene, these cell lines allow for the observation of altered cellular pathways, including those involved in cell signaling, motility, and sensory perception, as the RSPH3 gene is pivotal in the formation and maintenance of cilia. Researchers can utilize these knockout lines to assess how the absence of this gene affects cellular functions and to identify potential therapeutic targets.
The scientific significance of this product lies in its application across various research fields, including developmental biology, cell biology, and genetics. In clinical settings, understanding the ramifications of RSPH3 loss can contribute to the development of targeted therapies for disorders associated with defective cilia. The high fidelity of these knockout cell lines represents a vital tool for elucidating gene function, validating drug targets, and screening potential therapeutic compounds.
One of the standout advantages of RSPH3 Gene Knockout Cell Lines compared to alternatives is their robustness and reliability in experimental setups. These cell lines undergo rigorous validation and characterization, ensuring consistency and reproducibility across studies. Our product also offers extensive customization options, allowing researchers to adapt cell lines to suit specific experimental needs, hence enhancing their research outcomes.
For researchers and clinicians, RSPH3 Gene Knockout Cell Lines are invaluable resources that facilitate the exploration of gene function in health and disease. By utilizing these advanced models, users can accelerate their research efforts, fostering new discoveries that may lead to innovative treatment strategies.
Our company specializes in providing high-quality biological products tailored to meet the evolving needs of the scientific community. With an emphasis on innovation and reliability, we are committed to supporting researchers in their quest to unravel the complexities of biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.