Gene: RNF216
Official Full Name: ring finger protein 216provided by HGNC
Gene Summary: This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01993 | RNF216 Knockout cell line (HeLa) | Human | RNF216 | 1:3~1:6 | Negative | Online Inquiry |
KO01994 | RNF216 Knockout cell line (HCT 116) | Human | RNF216 | 1:2~1:4 | Negative | Online Inquiry |
KO01995 | RNF216 Knockout cell line (HEK293) | Human | RNF216 | 1:3~1:6 | Negative | Online Inquiry |
KO01996 | RNF216 Knockout cell line (A549) | Human | RNF216 | 1:3~1:4 | Negative | Online Inquiry |
RNF216 Gene Knockout Cell Lines are specifically engineered cellular models designed to enable in-depth studies of the RNF216 gene's role in various biological processes and disease mechanisms. Through targeted gene editing techniques such as CRISPR-Cas9, these cell lines exhibit a complete knockout of the RNF216 gene, allowing researchers to dissect the gene's biological functions and contribute valuable insights into its involvement in neurodegenerative diseases, immune responses, and cellular signaling pathways.
The primary function of RNF216 Gene Knockout Cell Lines is to serve as a platform for investigating the consequences of gene loss on cellular behavior and phenotype. By observing the alterations in cell proliferation, apoptosis, and signaling cascades in the absence of RNF216, researchers can elucidate the gene's contributions to both normal physiology and pathological states. The precise gene knockout technique ensures specific and reproducible alterations in gene expression, making these cell lines ideal for functional assays.
Scientifically, RNF216 Gene Knockout Cell Lines hold substantial significance in the research community, particularly in understanding complex biological interactions and developing therapeutic strategies against diseases where RNF216 is implicated. Their application extends to drug discovery, where the cell lines can be used to screen for compounds that may target pathways disrupted by the lack of RNF216, highlighting their utility in both academic and clinical research settings.
What sets RNF216 Gene Knockout Cell Lines apart from traditional models is their specificity and reliability. Unlike random mutagenesis or overexpression systems, these knockout models provide a precise tool for investigating gene function without confounding effects. Furthermore, they enable high reproducibility in experimental results, which is critical for advancing research.
For researchers and clinicians, this product represents a valuable resource, streamlining the process of functional genomics investigation and accelerating the understanding of genetic contributions to disease. The availability of high-quality, validated cell lines enhances experimental rigor and provides a dependable basis for groundbreaking discoveries.
With our extensive expertise in genetic engineering and commitment to providing superior biological products, we offer RNF216 Gene Knockout Cell Lines as a crucial addition to your research arsenal, facilitating innovative approaches to gene function analysis and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.