Gene: RNF208
Official Full Name: ring finger protein 208provided by HGNC
Gene Summary: Enables ubiquitin-protein transferase activity. Involved in protein autoubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14457 | RNF208 Knockout cell line (HeLa) | Human | RNF208 | 1:3~1:6 | Negative | Online Inquiry |
KO14458 | RNF208 Knockout cell line (HCT 116) | Human | RNF208 | 1:2~1:4 | Negative | Online Inquiry |
KO14459 | RNF208 Knockout cell line (HEK293) | Human | RNF208 | 1:3~1:6 | Negative | Online Inquiry |
RNF208 Gene Knockout Cell Lines are specialized biological tools engineered to lack the expression of the RNF208 gene, which is known to play a significant role in cellular processes, particularly within the context of cancer biology and cell signaling. These cell lines are invaluable for researchers aiming to elucidate the precise functions of RNF208 in various biological pathways, including its impact on protein stability, gene expression modulation, and its implications in tumorigenesis.
The mechanism by which RNF208 gene knockout works relies on advanced genome editing technologies, such as CRISPR/Cas9, which enable the targeted disruption of the RNF208 gene. By creating a loss-of-function model, scientists can study the downstream effects of RNF208 absence, gaining insights into its role in cellular stress responses, DNA repair mechanisms, and other critical processes. This powerful approach not only facilitates the understanding of RNF208's specific functions but also offers platforms for testing therapeutic strategies that could exploit these mechanisms.
The scientific importance of RNF208 Gene Knockout Cell Lines extends into numerous fields, particularly cancer research, where understanding gene function can lead to the identification of novel biomarkers and therapeutic targets. In clinical settings, these cell lines can also be instrumental for drug development and efficacy testing, providing a reliable model for screening potential anti-cancer agents targeting pathways influenced by RNF208.
Compared to traditional cell lines, RNF208 Gene Knockout Cell Lines offer distinct advantages. Namely, they provide a sharper focus on the biological contributions of RNF208 without the confounding influences of this gene's activity. This specificity can significantly enhance the validity of experimental outcomes, thereby accelerating the pace of research and development.
For researchers and clinicians alike, the value of using RNF208 Gene Knockout Cell Lines lies in their capacity to deliver precise, replicable insights that are crucial for advancing our understanding of complex disease mechanisms. Ultimately, this product empowers scientists to explore innovative therapies that could lead to breakthroughs in treatment strategies.
Our company prides itself on its dedication to providing high-quality biological products tailored to the needs of the research community. With expertise in genomic technologies, we strive to support groundbreaking discoveries that will enhance scientific knowledge and improve human health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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