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RNF167 Knockout Cell Lines

Gene: RNF167

Official Full Name: ring finger protein 167provided by HGNC

Gene Summary: RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00498 RNF167 Knockout cell line (A549) Human RNF167 1:3~1:4 Negative Online Inquiry
KO04523 RNF167 Knockout cell line (HeLa) Human RNF167 1:3~1:6 Negative Online Inquiry
KO04524 RNF167 Knockout cell line (HCT 116) Human RNF167 1:2~1:4 Negative Online Inquiry
KO04525 RNF167 Knockout cell line (HEK293) Human RNF167 1:3~1:6 Negative Online Inquiry

Background

RNF167 Gene Knockout Cell Lines are specifically engineered cell lines in which the RNF167 gene has been inactivated through targeted gene editing techniques, such as CRISPR/Cas9. This product enables researchers to study the functional role of RNF167, a gene implicated in various cellular processes, including protein ubiquitination and immune response modulation. The knockout of this gene facilitates investigations into the biological pathways and mechanisms where RNF167 plays a critical role.

The key function of these cell lines lies in their ability to serve as a model for examining the consequences of RNF167 disruption on cellular behavior, including proliferation, apoptosis, and response to stress. By comparing these knockout lines with their wild-type counterparts, researchers can elucidate the specific functions of RNF167 in diverse biological contexts, potentially leading to insights in oncogenesis, autoimmune disorders, and signaling pathways involved in cellular homeostasis.

Scientifically, RNF167 Gene Knockout Cell Lines are invaluable tools in both basic and applied research. In clinical settings, they are pivotal for the development of therapies targeting RNF167-related conditions, thereby allowing for the screening of drug candidates that may either restore normal function or exploit the deficits caused by the knockout.

One of the significant advantages these cell lines offer is the high specificity and efficiency of the knockout, minimizing off-target effects often associated with other gene editing methodologies. Additionally, their ease of use and reproducibility make them accessible for a broad range of researchers, from those new to gene editing to seasoned professionals.

For researchers and clinicians alike, RNF167 Gene Knockout Cell Lines represent a crucial resource for advancing understanding in gene function and pathology, leading to actionable insights that could pave the way for novel therapeutic approaches. Our company, recognized for its commitment to providing high-quality biological products, ensures that these cell lines meet stringent standards for authenticity and reliability, thus supporting the scientific community in their quest for discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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