Home / RNASE1 Knockout Cell Lines

RNASE1 Knockout Cell Lines

Gene: RNASE1

Official Full Name: ribonuclease A family member 1, pancreaticprovided by HGNC

Gene Summary: This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00901 RNASE1 Knockout cell line(THP-1) Human RNASE1 1:2-1:4 Negative Online Inquiry
KO14495 RNASE1 Knockout cell line (HCT 116) Human RNASE1 1:2~1:4 Negative Online Inquiry
KO14496 RNASE1 Knockout cell line (A549) Human RNASE1 1:3~1:4 Negative Online Inquiry

Background

RNASE1 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the RNASE1 gene, which encodes the ribonuclease enzyme important for RNA degradation in various biological processes. By employing CRISPR-Cas9 gene editing technology, these knockout cell lines exhibit a complete or substantial loss of RNASE1 expression, allowing researchers to investigate the gene's functions and regulatory mechanisms in a controlled manner.

The key functionality of RNASE1 Gene Knockout Cell Lines lies in their ability to mimic specific biological scenarios where RNASE1 activity is diminished or absent. This enables the elucidation of the gene's role in cellular processes such as apoptosis, cellular stress responses, and viral defense mechanisms. Additionally, these knockout models can be instrumental in drug discovery and toxicity screening, allowing for detailed investigation into how RNASE1's absence alters cellular responses to pharmacological agents.

Scientifically, the RNASE1 knockout models are invaluable in both research and clinical settings. They provide insights into fundamental cellular mechanisms, contributing to broader studies in cancer biology, virology, and gene therapy approaches. Researchers can utilize these cell lines to model diseases associated with altered ribonuclease activity, paving the way for therapeutic interventions and novel treatment modalities.

Compared to alternative cell models, the RNASE1 Gene Knockout Cell Lines offer precise targeting and reliability, ensuring that any observed phenotype is directly attributable to the lack of RNASE1 function. This specificity reduces background noise and enhances the clarity of experimental outcomes, ultimately leading to more robust scientific conclusions.

The value of RNASE1 Gene Knockout Cell Lines to researchers and clinicians cannot be overstated: they provide a critical tool for advancing our understanding of RNA metabolism and the physiological roles of ribonucleases. Their use can accelerate the pace of discovery in numerous critical areas of biomedical research.

Our company is committed to delivering high-quality biological products that empower the scientific community. With years of expertise in genetic engineering and a robust portfolio of innovative tools, we ensure that our RNASE1 Gene Knockout Cell Lines meet the highest standards of quality and reliability for your research needs.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.