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RLN1 Knockout Cell Lines

Gene: RLN1

Official Full Name: relaxin 1provided by HGNC

Gene Summary: Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35615 RLN1 Knockout cell line (A549) Human RLN1 1:3~1:4 Negative Online Inquiry

Background

RLN1 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the relaxin-1 (RLN1) gene's role in various biological processes. By employing the CRISPR-Cas9 gene-editing technology, these cell lines have undergone precise modifications to produce a complete knockout of the RLN1 gene, enabling researchers to explore its functions and contributions to physiological and pathological conditions.

The primary function of the RLN1 Gene Knockout Cell Lines lies in their ability to mimic the absence of relaxin-1, a peptide hormone that plays crucial roles in reproductive physiology, cardiovascular function, and tissue remodeling. With these knockout models, researchers can investigate the downstream biological effects of RLN1 absence, such as altered cellular signaling pathways, morphology changes, and modifications in gene expression profiles, ultimately shedding light on diseases influenced by relaxin dysregulation.

The scientific importance of these cell lines extends to applications in both basic research and clinical settings. They serve as vital tools for drug discovery, enabling investigations into potential therapeutic targets for conditions such as heart failure and fibrotic diseases. Additionally, RLN1 Gene Knockout Cell Lines provide insights into the hormone’s involvement in cancer progression, where altered relaxin signaling has been implicated.

One notable advantage of using RLN1 Gene Knockout Cell Lines is their specificity and precision compared to conventional knockdown approaches. Unlike RNA interference techniques, which can lead to incomplete knockdown and off-target effects, gene knockout ensures a complete and durable loss of function, allowing for more definitive conclusions about the gene's role. Furthermore, these cell lines can be easily integrated into existing experimental workflows, thereby streamlining research processes and improving overall experimental reliability.

The value of RLN1 Gene Knockout Cell Lines is profound for researchers and clinicians aiming to uncover the complexities surrounding relaxin signaling pathways. Their ability to contribute to significant advancements in understanding health and disease makes them an indispensable resource in molecular biology and translational research efforts.

With a commitment to advancing scientific discovery, our company prides itself on delivering high-quality biological products, such as RLN1 Gene Knockout Cell Lines, backed by robust research and development. Our expertise ensures that clients have access to cutting-edge tools that propel their work forward in the dynamic field of life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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