Gene: RLIM
Official Full Name: ring finger protein, LIM domain interactingprovided by HGNC
Gene Summary: The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22975 | RLIM Knockout cell line (HeLa) | Human | RLIM | 1:3~1:6 | Negative | Online Inquiry |
KO22976 | RLIM Knockout cell line (HCT 116) | Human | RLIM | 1:2~1:4 | Negative | Online Inquiry |
KO22977 | RLIM Knockout cell line (HEK293) | Human | RLIM | 1:3~1:6 | Negative | Online Inquiry |
KO22978 | RLIM Knockout cell line (A549) | Human | RLIM | 1:3~1:4 | Negative | Online Inquiry |
RLIM Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to facilitate the study of the RLIM (RING Finger protein 12) gene by providing a model that completely lacks its functional expression. This product is invaluable for researchers seeking to elucidate the biological roles and pathways associated with RLIM, which has been linked to various cellular processes including gene expression regulation, protein degradation, and cellular differentiation.
The primary function of these knockout cell lines lies in their ability to allow scientists to observe phenotypic changes and molecular interactions resulting from the absence of RLIM. By comparing the behavior of RLIM knockout cells to wild-type controls, researchers can gain significant insights into the gene’s role in pathophysiological conditions such as cancer, neurodegeneration, and developmental disorders. This is achieved through a precise genome editing technique, typically utilizing CRISPR/Cas9, which introduces targeted deletions in the RLIM gene, thus providing an accurate model of gene function.
The scientific importance of RLIM Gene Knockout Cell Lines extends to both basic and applied research arenas. They serve as critical tools for drug discovery, functional genomics, and disease modeling, allowing for a more comprehensive understanding of gene function in health and disease. Their application in clinical settings could pave the way for targeted therapeutic strategies aimed at modulating RLIM-related pathways.
When compared to alternative models such as siRNA or shRNA silencing approaches, the advantage of using RLIM knockout cell lines is their permanent and complete gene ablation, ensuring consistent and reproducible results across experiments. This stability enhances the reliability of research outcomes and facilitates long-term studies on gene function without the complications related to transient knockdown methods.
For researchers, clinicians, and pharmaceutical companies, the RLIM Gene Knockout Cell Lines represent a crucial advance in the toolkit available for gene function analysis. This product empowers users to unravel complex biological mechanisms with confidence, ultimately contributing to advancements in therapeutic approaches.
Our company specializes in providing high-quality genetic models and is committed to offering innovative solutions that enhance research capabilities. With our extensive expertise in genetic engineering and a focus on customer satisfaction, we are dedicated to supporting the scientific community in their quest for knowledge.
Please note that all services are for research use only. Not intended for any clinical use.
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