Gene: RIPOR1
Official Full Name: RHO family interacting cell polarization regulator 1provided by HGNC
Gene Summary: Enables 14-3-3 protein binding activity. Involved in several processes, including establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange factor activity; and negative regulation of Rho protein signal transduction. Located in Golgi apparatus; cell leading edge; and membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05303 | RIPOR1 Knockout cell line (HeLa) | Human | RIPOR1 | 1:3~1:6 | Negative | Online Inquiry |
KO05304 | RIPOR1 Knockout cell line (HCT 116) | Human | RIPOR1 | 1:2~1:4 | Negative | Online Inquiry |
KO05305 | RIPOR1 Knockout cell line (HEK293) | Human | RIPOR1 | 1:3~1:6 | Negative | Online Inquiry |
KO05306 | RIPOR1 Knockout cell line (A549) | Human | RIPOR1 | 1:3~1:4 | Negative | Online Inquiry |
RIPOR1 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to eliminate the expression of the RIPOR1 gene, which plays a critical role in cellular processes such as immune response and inflammation regulation. By employing CRISPR/Cas9 technology, these cell lines ensure precise and efficient gene disruption, enabling researchers to study the functional implications of RIPOR1 in various biological contexts.
The primary mechanism of RIPOR1 gene knockout involves the introduction of specific guide RNAs that target the RIPOR1 gene, leading to site-specific double-strand breaks. Subsequent repair processes, often resulting in insertions or deletions, disrupt the gene’s coding sequence, thus creating a functional knockout. This allows for in-depth investigations into how RIPOR1 alterations affect cellular behaviors, such as migration, proliferation, and apoptosis, especially within the immune system and its interactions with other cell types.
The scientific significance of RIPOR1 Gene Knockout Cell Lines lies in their ability to facilitate groundbreaking research in immunology, cancer biology, and therapeutic development. By providing a tool to dissect the pathway mediated by RIPOR1, researchers can uncover potential biomarkers, identify drug targets, and develop novel interventions aimed at diseases linked to dysregulated immune responses.
Compared to traditional knockout methods, the CRISPR/Cas9 system employed in creating these cell lines offers unparalleled precision and efficiency, reducing off-target effects and allowing for the generation of stable cell lines in a fraction of the time. Additionally, these cell lines come ready for use, supporting rapid experimental timelines and robust data generation.
For researchers and clinicians focused on exploring the complex role of RIPOR1, these knockouts present an unparalleled opportunity to advance their understanding and contribute to the development of targeted therapies. Our company prides itself on leveraging cutting-edge genetic engineering techniques to deliver high-quality biological products, ensuring that you have the necessary tools to propel your research forward.
Please note that all services are for research use only. Not intended for any clinical use.
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