Gene: RILPL1
Official Full Name: Rab interacting lysosomal protein like 1provided by HGNC
Gene Summary: Predicted to enable dynein light intermediate chain binding activity and small GTPase binding activity. Predicted to be involved in several processes, including epithelial cell morphogenesis; nitric oxide mediated signal transduction; and protein transport from ciliary membrane to plasma membrane. Located in cytosol; nucleoplasm; and plasma membrane. Implicated in oculopharyngodistal myopathy 4. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14528 | RILPL1 Knockout cell line (HeLa) | Human | RILPL1 | 1:3~1:6 | Negative | Online Inquiry |
KO14529 | RILPL1 Knockout cell line (HCT 116) | Human | RILPL1 | 1:2~1:4 | Negative | Online Inquiry |
KO14530 | RILPL1 Knockout cell line (HEK293) | Human | RILPL1 | 1:3~1:6 | Negative | Online Inquiry |
KO14531 | RILPL1 Knockout cell line (A549) | Human | RILPL1 | 1:3~1:4 | Negative | Online Inquiry |
RILPL1 Gene Knockout Cell Lines are specialized cellular models generated through the targeted deletion of the RILPL1 gene, which encodes the Rab-interacting lysosomal protein. These cell lines serve as crucial tools for studying the functional role of RILPL1 in cellular biology, particularly its involvement in lysosomal dynamics, autophagy, and cellular signaling pathways. The knockout of RILPL1 leads to distinct phenotypic changes, including variations in lysosomal morphology and impaired autophagic flux, providing a clear understanding of the gene's contributions to cellular homeostasis.
The primary function of these cell lines lies in elucidating the mechanistic pathways regulated by RILPL1, enabling researchers to investigate its impact on various cellular processes such as organelle trafficking, signal transduction, and stress responses. The absence of RILPL1 allows for the observation of compensatory mechanisms or alternative pathways activated in lysosomal dysfunction, thereby enhancing our knowledge of related diseases and potential therapeutic targets.
Scientifically, RILPL1 Gene Knockout Cell Lines hold significant applications in both research and clinical settings. They are particularly valuable for studying lysosomal-related diseases, such as neurodegenerative disorders, and for drug screening and development aimed at restoring lysosomal function. Moreover, these cell lines can be utilized to investigate the molecular bases of various pathologies linked to autophagy and endolysosomal trafficking disruptions.
A notable advantage of utilizing these knockout cell lines is the specificity and reproducibility they offer compared to other methods such as RNA interference, where off-target effects may occur. These cell lines provide a clean slate for researchers, allowing for clear interpretation of results and potentially faster pathways to novel discoveries.
For researchers and clinicians focused on advancing our understanding of lysosomal biology and its implications in disease, RILPL1 Gene Knockout Cell Lines are invaluable. They empower users with the tools needed to dissect complex cellular pathways contributing to health and disease, paving the way for innovative therapeutic strategies.
Our company specializes in providing high-quality, reliable biological products, and our expertise in creating customized gene knockout models ensures that you have access to tools that enhance the clarity and depth of your research. Whether you're investigating fundamental cellular processes or translational applications, our RILPL1 Gene Knockout Cell Lines offer unique advantages to propel your work forward.
Please note that all services are for research use only. Not intended for any clinical use.
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