Home / RIGI Knockout Cell Lines

RIGI Knockout Cell Lines

Gene: RIGI

Official Full Name: RNA sensor RIG-Iprovided by HGNC

Gene Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14532 RIGI Knockout cell line (HeLa) Human RIGI 1:3~1:6 Negative Online Inquiry
KO14533 RIGI Knockout cell line (HCT 116) Human RIGI 1:2~1:4 Negative Online Inquiry
KO14534 RIGI Knockout cell line (HEK293) Human RIGI 1:3~1:6 Negative Online Inquiry
KO14535 RIGI Knockout cell line (A549) Human RIGI 1:3~1:4 Negative Online Inquiry

Background

RIGI Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, providing researchers with a well-characterized and versatile platform for gene function analysis. These cell lines are engineered using advanced CRISPR/Cas9 gene-editing technology to create specific knockouts of targeted genes, thereby allowing for the study of the effects of gene loss on cellular processes. This precise disruption facilitates the investigation of gene function, protein interactions, and signaling pathways that underlie various biological phenomena.

The primary mechanism behind RIGI Gene Knockout Cell Lines involves the introduction of double-strand breaks at specific genomic loci through the Cas9 nuclease, followed by the introduction of indel mutations during the cell's natural repair process. This targeted gene knockout results in loss of protein expression, enabling users to assess phenotypic changes, including alterations in cell proliferation, differentiation, and apoptosis. Researchers can utilize these cell lines not only for basic science applications but also for drug development, toxicity studies, and disease modeling, making them invaluable in both academic and clinical research environments.

RIGI stands out in the market due to its extensive validation process, ensuring that each knockout cell line comes with comprehensive genomic and phenotypic characterization. Unlike traditional methods that may suffer from off-target effects or incomplete gene disruption, RIGI's CRISPR-based approach offers higher specificity and efficiency. This leads to more reliable results, which are crucial for reproducible research findings.

Given the increasing demand for precise genetic manipulation tools in the life sciences education and pharmaceutical sectors, RIGI Gene Knockout Cell Lines provide superior reliability and function, making them essential for those pursuing groundbreaking discoveries. Researchers and clinicians can leverage these cell lines to accelerate their studies and enhance the quality of their experimental outputs.

With years of expertise in genetic engineering and cell line development, our company is committed to providing high-quality biological products that empower scientific innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.