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RICTOR Knockout Cell Lines

Gene: RICTOR

Official Full Name: RPTOR independent companion of MTOR complex 2provided by HGNC

Gene Summary: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00299 RICTOR Knockout cell line(HEK293) Human RICTOR 1:3~1:6 Negative Online Inquiry
KO09080 RICTOR Knockout cell line (HeLa) Human RICTOR 1:3~1:6 Negative Online Inquiry
KO09081 RICTOR Knockout cell line (HCT 116) Human RICTOR 1:2~1:4 Negative Online Inquiry
KO09082 RICTOR Knockout cell line (A549) Human RICTOR 1:3~1:4 Negative Online Inquiry

Background

RICTOR Gene Knockout Cell Lines represent a crucial tool in modern biological research, specifically tailored for investigating the functions of the RICTOR gene, a pivotal component of the mTOR signaling pathway. This gene is intimately involved in various cellular processes, including growth, metabolism, and survival, making its study essential for understanding cellular responses to environmental cues. The creation of these knockout cell lines allows scientists to systematically investigate the specific roles of RICTOR by observing the phenotypic effects of its absence.

The key function of RICTOR gene knockout cell lines lies in their ability to provide a controlled genetic environment for experiments. By utilizing CRISPR/Cas9 technology or other gene-editing methods, the RICTOR gene is effectively disrupted, allowing for the elucidation of downstream signaling events and cellular behavior changes. Researchers can interpret the roles of RICTOR in the context of cancer biology, metabolic disorders, and other diseases that are linked to mTOR pathway dysregulation.

The scientific importance of these knockout cell lines extends to various applications in both research and clinical settings. They facilitate studies aimed at developing targeted therapies for cancers where the mTOR pathway is aberrantly activated. Furthermore, these cell lines can be instrumental in drug validation processes, aiding in the identification of compounds that may restore normal signaling functions.

In comparison to alternatives such as overexpression systems or RNA interference models, RICTOR gene knockout cell lines offer several advantages. They provide a more definitive and complete loss-of-function scenario, allowing for clearer insights into RICTOR's role without the confounding effects of residual activity that can occur in partial knockdown strategies.

For researchers, clinicians, and pharmaceutical developers, RICTOR Gene Knockout Cell Lines serve as invaluable assets to advance understanding of complex biological systems and expedite the discovery of novel therapeutic strategies. By investing in this product, users gain access to meticulously engineered cell lines that promise reproducible and reliable results.

Our company prides itself on a rich history of expertise in developing innovative biological products designed to empower researchers and healthcare providers alike, ensuring that they remain at the forefront of scientific advancement in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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