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RHOB Knockout Cell Lines

Gene: RHOB

Official Full Name: ras homolog family member Bprovided by HGNC

Gene Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38945 RHOB Knockout cell line (HeLa) Human RHOB 1:3~1:6 Negative Online Inquiry
KO38946 RHOB Knockout cell line (HCT 116) Human RHOB 1:2~1:4 Negative Online Inquiry
KO38947 RHOB Knockout cell line (HEK293) Human RHOB 1:3~1:6 Negative Online Inquiry
KO38948 RHOB Knockout cell line (A549) Human RHOB 1:3~1:4 Negative Online Inquiry

Background

RHOB Gene Knockout Cell Lines are specifically developed cellular models in which the RHOB gene, known for its role in regulating various cellular processes such as cell adhesion, migration, and proliferation, has been inactivated using CRISPR-Cas9 gene editing technology. The knockout of the RHOB gene facilitates extensive studies of its biological functions and the molecular pathways it influences, allowing researchers to explore the effects of its absence in a controlled environment.

The key function of these cell lines lies in their ability to mimic pathological conditions associated with altered RHOB expression, such as certain cancers and cardiovascular diseases. By utilizing these knockout cell lines, researchers can systematically dissect the signaling mechanisms that are impacted by loss-of-function mutations in RHOB. Moreover, the ability to observe changes in cell behavior, including alterations in motility and invasion, provides significant insights into tumor metastasis and other related phenomena.

Scientifically, RHOB Gene Knockout Cell Lines are invaluable in both basic and applied research, offering a robust tool for drug discovery and therapeutic target validation. Their utility extends into clinical settings where understanding RHOB function can pave the way for novel treatment strategies for diseases linked to cell motility and proliferation dysregulation.

When compared to alternatives like siRNA methods or traditional knockout strategies, RHOB Gene Knockout Cell Lines provide a more stable and permanent solution for gene inactivation. This stability allows for long-term experiments and characterizations without the rapid degradation or variability associated with transient knockdown methodologies.

This product is of particular value to researchers and clinicians focused on cellular dynamics, oncology, and developmental biology, as it enhances their ability to model diseases accurately and to discover novel therapeutic interventions. Utilizing these tailored cell lines can significantly expedite the research process while providing high fidelity data relevant to human health.

Our company is dedicated to advancing scientific research through high-quality biological products. With extensive expertise in cellular models and gene editing technologies, we offer reliable solutions that empower researchers to uncover the complexities of gene function and improve healthcare outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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