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RGS14 Knockout Cell Lines

Gene: RGS14

Official Full Name: regulator of G protein signaling 14provided by HGNC

Gene Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08643 RGS14 Knockout cell line (HeLa) Human RGS14 1:3~1:6 Negative Online Inquiry
KO08644 RGS14 Knockout cell line (HCT 116) Human RGS14 1:2~1:4 Negative Online Inquiry
KO08645 RGS14 Knockout cell line (A549) Human RGS14 1:3~1:4 Negative Online Inquiry

Background

RGS14 Gene Knockout Cell Lines are genetically modified cellular models designed specifically to elucidate the functional roles of the RGS14 (Regulator of G-protein signaling 14) gene in various biological processes. This product offers researchers a powerful tool for investigating the intricate pathways of G-protein coupled receptor (GPCR) signaling, as RGS14 plays a crucial role in modulating these pathways in response to extracellular stimuli.

The primary function of RGS14 includes acting as a scaffold for GPCRs and their downstream signaling components, thereby influencing cellular responses to hormones and neurotransmitters. By utilizing RGS14 Gene Knockout Cell Lines, scientists can precisely assess the effects of RGS14 loss on signaling dynamics, cellular proliferation, migration, and differentiation. This mechanistic insight is particularly relevant in the context of cancer biology, neurobiology, and cardiovascular research, where aberrant GPCR signaling is often implicated.

In research and clinical settings, the ability to study these knockouts provides a clearer understanding of disease mechanisms and potential therapeutic targets. RGS14 has emerged as a key player in a variety of pathological states, making these cell lines invaluable for the development of novel intervention strategies.

One of the primary advantages of RGS14 Gene Knockout Cell Lines lies in their specificity and reliability compared to other models. While traditional knockdown methods may inadvertently target related genes, our knockout system enables complete abrogation of RGS14 expression. Additionally, our rigorous validation processes ensure that these cell lines exhibit consistent characteristics and reproducible results, enhancing the reliability of experimental outcomes.

Researchers and clinicians will appreciate the value of RGS14 Gene Knockout Cell Lines for their contributions to advancing the understanding of GPCR signaling and related diseases. They serve as an essential resource for both fundamental research and translational applications, positioning our customers at the forefront of scientific innovation.

We pride ourselves on our expertise in producing high-quality genetic models, leveraging cutting-edge technologies and a commitment to scientific excellence. By choosing our RGS14 Gene Knockout Cell Lines, you are equipping your research with superior tools that can yield impactful discoveries in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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