Gene: RFK
Official Full Name: riboflavin kinaseprovided by HGNC
Gene Summary: Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).[supplied by OMIM, Nov 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14588 | RFK Knockout cell line (HeLa) | Human | RFK | 1:3~1:6 | Negative | Online Inquiry |
KO14589 | RFK Knockout cell line (HCT 116) | Human | RFK | 1:2~1:4 | Negative | Online Inquiry |
KO14590 | RFK Knockout cell line (HEK293) | Human | RFK | 1:3~1:6 | Negative | Online Inquiry |
KO14591 | RFK Knockout cell line (A549) | Human | RFK | 1:3~1:4 | Negative | Online Inquiry |
RFK Gene Knockout Cell Lines are a state-of-the-art biological research tool created to facilitate the study of riboflavin metabolism and associated diseases by specifically knocking out the riboflavin kinase (RFK) gene within a cell line. These engineered cell lines leverage CRISPR-Cas9 technology, allowing for precise genomic alterations that enable researchers to investigate the functional implications of RFK deficiency. By eliminating RFK expression, researchers can better understand the role of riboflavin in physiological pathways, nutrient absorption, and its impact on metabolic disorders.
The primary function of RFK Gene Knockout Cell Lines is to offer a model system that mimics the metabolic anomalies found in riboflavin deficiency, thereby allowing researchers to explore the underlying biological mechanisms in a controlled environment. This capability is crucial in the field of metabolic research, where understanding gene function and its subsequent impact on metabolism can lead to greater insights into various pathologies, including cancer, diabetes, and cardiovascular diseases.
The scientific importance of these cell lines in research settings is profound, as they provide a robust platform for pharmacological studies aimed at identifying potential therapeutic targets. Moreover, they enhance our understanding of vitamin B2's biological role and its contribution to cellular health, paving the way for novel interventions in clinical settings.
What sets RFK Gene Knockout Cell Lines apart from alternative models is their specificity and versatility. Unlike broadly targeted gene inhibitors, these knockout lines offer a more precise approach to studying gene function, significantly reducing off-target effects and increasing the reliability of experimental data. Furthermore, these cell lines are readily available and easily cultured, streamlining the research process.
For researchers and clinicians alike, RFK Gene Knockout Cell Lines represent a valuable asset in the quest to discover and develop innovative treatments. Their detailed genetic modification allows for tailored investigations into riboflavin-related pathways, fostering breakthroughs in clinical applications aimed at addressing metabolic deficiencies.
As a leader in the field of biological products, our company is dedicated to advancing research by providing high-quality, tailored cellular models. With a commitment to scientific excellence and innovation, we empower researchers to push the boundaries of knowledge and translate their findings into impactful solutions for human health.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.