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RETREG2 Knockout Cell Lines

Gene: RETREG2

Official Full Name: reticulophagy regulator family member 2provided by HGNC

Gene Summary: Predicted to enable endoplasmic reticulum-autophagosome adaptor activity. Predicted to be involved in autophagy. Predicted to act upstream of or within collagen catabolic process; endoplasmic reticulum organization; and reticulophagy. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14608 RETREG2 Knockout cell line (HeLa) Human RETREG2 1:3~1:6 Negative Online Inquiry
KO14609 RETREG2 Knockout cell line (HCT 116) Human RETREG2 1:2~1:4 Negative Online Inquiry
KO14610 RETREG2 Knockout cell line (HEK293) Human RETREG2 1:3~1:6 Negative Online Inquiry
KO14611 RETREG2 Knockout cell line (A549) Human RETREG2 1:3~1:4 Negative Online Inquiry

Background

RETREG2 Gene Knockout Cell Lines represent a groundbreaking advancement in the study of cellular mechanisms and disease processes. These cell lines are specifically engineered to have a targeted disruption of the RETREG2 gene, which plays a crucial role in regulating endoplasmic reticulum (ER) stress responses and autophagy. By utilizing CRISPR-Cas9 technology, RETREG2 knockout cells allow researchers to observe the functional implications of RETREG2 absence on cellular homeostasis, protein folding, and stress management processes.

The key function of RETREG2 is its involvement in modulating the UPR (unfolded protein response) and autophagy pathways, essential for maintaining cellular integrity under stress conditions. By studying these knockout cell lines, scientists can elucidate the pathways affected by RETREG2 and their contributions to various pathophysiological conditions, including neurodegenerative diseases, cancer, and metabolic syndromes.

The scientific importance of these knockout cell lines lies in their multifaceted applications in both basic and translational research. They serve as powerful tools for probing gene function and regulatory networks, enabling the identification of potential therapeutic targets. Furthermore, RETREG2 knockout cell lines can facilitate drug discovery by providing a model to assess the efficacy and mechanism of action of new pharmacological agents in a controlled environment.

What sets RETREG2 Gene Knockout Cell Lines apart from other biological tools is their specificity and ease of use. Unlike traditional methods of gene knockdown, such as RNA interference, CRISPR-based knockouts provide complete and stable gene disruption, leading to clearer and more interpretable results. Additionally, these cell lines are characterized by robust viability, ensuring that researchers can perform a variety of assays necessary for comprehensive analysis.

The value of RETREG2 Gene Knockout Cell Lines is underscored by their ability to accelerate research and clinical discoveries by providing deep insights into cellular stress mechanisms and disease progression. They empower researchers, clinicians, and pharmaceutical developers with the critical knowledge needed to tackle complex biological questions and translate findings into therapeutic innovations.

In conclusion, [Your Company Name] leverages extensive expertise in cellular biology and genetic engineering to provide high-quality biological products like the RETREG2 Gene Knockout Cell Lines. Committed to supporting the scientific community, we prioritize innovation, quality, and accessibility to enhance research outcomes and drive advancements in healthcare.

Please note that all services are for research use only. Not intended for any clinical use.

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