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RBM3 Knockout Cell Lines

Gene: RBM3

Official Full Name: RNA binding motif protein 3provided by HGNC

Gene Summary: This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01882 RBM3 Knockout cell line (HeLa) Human RBM3 1:3~1:6 Negative Online Inquiry
KO01883 RBM3 Knockout cell line (HCT 116) Human RBM3 1:2~1:4 Negative Online Inquiry
KO01884 RBM3 Knockout cell line (HEK293) Human RBM3 1:3~1:6 Negative Online Inquiry
KO01885 RBM3 Knockout cell line (A549) Human RBM3 1:3~1:4 Negative Online Inquiry

Background

RBM3 Gene Knockout Cell Lines are specifically engineered cellular models designed to investigate the functional roles of the RBM3 gene, known for its involvement in cellular stress responses, neuroprotection, and the modulation of alternative splicing. Utilizing CRISPR-Cas9 gene editing technology, these knockout cell lines selectively eliminate the expression of the RBM3 gene, allowing researchers to delve deeper into the mechanisms by which RBM3 influences critical biological pathways and its implications in various disease states.

The primary function of these cell lines is to facilitate the examination of RBM3's role in cellular processes such as apoptosis, cell proliferation, and differentiation under stress conditions. By providing a controlled environment to study the gene’s absence, researchers can elucidate the phenotypic and molecular changes that occur when RBM3 is not present, offering insights into its contribution to neurodegenerative diseases and cancer, where the dysregulation of RNA-binding proteins is prevalent.

In the realm of scientific research and clinical applications, RBM3 Gene Knockout Cell Lines serve as invaluable tools for understanding the pathways involved in stress response and neuroprotection. Their utility extends to drug discovery and development, enabling the identification of novel therapeutic targets aimed at restoring RBM3 function in diseases associated with its dysregulation.

What sets these knockout cell lines apart from conventional models is their specificity and the precision of CRISPR-Cas9 technology, which minimizes off-target effects and ensures reproducibility in experiments. Additionally, the RBM3 knockout models are compatible with a variety of assays, including gene expression studies and functional assays, providing flexibility in experimental design.

For researchers and clinicians, leveraging RBM3 Gene Knockout Cell Lines means gaining access to a robust platform that not only enhances the understanding of gene function but also accelerates the pace of innovation in therapeutic development. Our company’s commitment to producing high-quality biological products, backed by rigorous research and quality control, ensures that our customers receive state-of-the-art tools for their scientific exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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