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RBCK1 Knockout Cell Lines

Gene: RBCK1

Official Full Name: RANBP2-type and C3HC4-type zinc finger containing 1provided by HGNC

Gene Summary: Enables several functions, including protein sequestering activity; transcription coactivator activity; and ubiquitin binding activity. Involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; protein linear polyubiquitination; and regulation of DNA-binding transcription factor activity. Part of LUBAC complex. Implicated in glycogen storage disease. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03857 RBCK1 Knockout cell line (HeLa) Human RBCK1 1:3~1:6 Negative Online Inquiry
KO03858 RBCK1 Knockout cell line (HCT 116) Human RBCK1 1:2~1:4 Negative Online Inquiry
KO03859 RBCK1 Knockout cell line (HEK293) Human RBCK1 1:3~1:6 Negative Online Inquiry
KO03860 RBCK1 Knockout cell line (A549) Human RBCK1 1:3~1:4 Negative Online Inquiry

Background

RBCK1 Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the expression of the RBCK1 gene, which encodes a protein involved in various cellular processes, including immune response, apoptosis, and cellular signaling pathways. By precisely knocking out the RBCK1 gene, these cell lines enable researchers to study the functional consequences of its absence, shedding light on its role in both normal physiology and disease states.

The key mechanism of action involves CRISPR-Cas9 gene editing technology, which allows for targeted modifications in the genome. This ensures a high specificity and efficiency in creating knockout models, significantly improving the reliability of experimental outcomes. In functional assays, these RBCK1 knockout cells can be utilized to investigate their impact on cell proliferation, differentiation, and responsiveness to stimuli, providing profound insights into the pathways influenced by RBCK1.

The scientific importance of RBCK1 Gene Knockout Cell Lines extends to diverse fields including cancer research, immunology, and neurobiology. Researchers can leverage these models to elucidate the mechanisms underlying disease progression, identify potential therapeutic targets, and validate new drug candidates in both in vitro and in vivo studies.

Compared to other gene-editing alternatives, such as RNA interference or traditional gene knockout methods, RBCK1 Gene Knockout Cell Lines offer the distinct advantage of achieving more stable and permanent gene disruption. This permanence is crucial for long-term studies, allowing for more consistent and reproducible experimental results.

These cell lines are invaluable resources for researchers and clinicians aiming to understand complex biological systems and their alterations in disease settings. By providing a robust platform for elucidating gene function and testing novel therapies, the RBCK1 Gene Knockout Cell Lines can significantly enhance the pace and quality of discovery in translational science.

Our company brings extensive expertise in genetic engineering and cellular biology, ensuring that our products meet rigorous scientific standards and support innovative research. With a commitment to quality and precision, we offer researchers the reliable tools needed to advance their understanding of biological processes.

Please note that all services are for research use only. Not intended for any clinical use.

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