Gene: RASSF1
Official Full Name: Ras association domain family member 1provided by HGNC
Gene Summary: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08968 | RASSF1 Knockout cell line (HeLa) | Human | RASSF1 | 1:3~1:6 | Negative | Online Inquiry |
KO08969 | RASSF1 Knockout cell line (HCT 116) | Human | RASSF1 | 1:2~1:4 | Negative | Online Inquiry |
KO08970 | RASSF1 Knockout cell line (HEK293) | Human | RASSF1 | 1:3~1:6 | Negative | Online Inquiry |
KO08971 | RASSF1 Knockout cell line (A549) | Human | RASSF1 | 1:3~1:4 | Negative | Online Inquiry |
RASSF1 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to harbor a specific deletion of the RASSF1 gene, a crucial regulator involved in various cellular processes such as cell cycle regulation, apoptosis, and tumor suppression. These knockout models allow researchers to study the functional consequences of RASSF1 loss in a controlled environment, facilitating insights into its role in oncogenesis and other pathological conditions.
The key function of RASSF1 knockout cell lines lies in their ability to mimic the altered signaling pathways characteristic of tumors lacking RASSF1 expression. By eliminating this gene, researchers can investigate downstream effects on key signaling cascades, such as the Ras-MAPK pathway, as well as variations in cell proliferation, survival rates, and the mechanisms of tumor progression. This enables a deeper understanding of the molecular underpinnings of cancer and potentially guides therapeutic innovations.
In the realm of scientific research and clinical applications, these knockout cell lines serve as invaluable tools for exploring targeted therapies, drug discovery, and personalized medicine approaches. Their importance is underscored by the increasing recognition of the RASSF1 gene's involvement in various malignancies, including lung and breast cancers, making them highly relevant in current oncological studies.
Compared to alternative models, RASSF1 Gene Knockout Cell Lines provide a robust and specific approach to gene function analysis. They exhibit reproducibility and reliability, ensuring that experimental results and interpretations are methodologically sound. Furthermore, these cell lines are readily available and easy to culture, making them accessible for a wide range of laboratories.
For researchers and clinicians striving to advance their understanding of cancer biology, RASSF1 Gene Knockout Cell Lines are a critical asset for unraveling complex tumor mechanisms and driving the development of new therapeutic strategies. Our company, with its extensive expertise in molecular biology and cutting-edge genetic engineering techniques, is committed to providing high-quality biological products that empower scientific discovery and foster innovations in health and disease management.
Please note that all services are for research use only. Not intended for any clinical use.
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