Gene: RASA3
Official Full Name: RAS p21 protein activator 3provided by HGNC
Gene Summary: This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08989 | RASA3 Knockout cell line (HeLa) | Human | RASA3 | 1:3~1:6 | Negative | Online Inquiry |
KO08990 | RASA3 Knockout cell line (HCT 116) | Human | RASA3 | 1:2~1:4 | Negative | Online Inquiry |
KO08991 | RASA3 Knockout cell line (HEK293) | Human | RASA3 | 1:3~1:6 | Negative | Online Inquiry |
KO08992 | RASA3 Knockout cell line (A549) | Human | RASA3 | 1:3~1:4 | Negative | Online Inquiry |
RASA3 Gene Knockout Cell Lines are highly specialized cellular models engineered to facilitate the in-depth study of RASA3 gene function and its role in various biological processes. RASA3, or Ras protein activator like 3, is a critical regulator involved in controlling cellular signaling pathways related to cell growth, differentiation, and survival. The RASA3 Gene Knockout Cell Lines utilize CRISPR/Cas9 technology to create targeted, precise deletions of the RASA3 gene, enabling researchers to analyze the resultant phenotypic changes and elucidate the gene's intricate mechanisms within cellular contexts.
The key functions of these knockout cell lines stem from their ability to mimic disease states where RASA3 is dysregulated. By silencing the gene, researchers can explore the downstream effects on Ras signaling cascades and assess how these changes impact cellular behaviors like proliferation, apoptosis, and migration. This capability is particularly valuable in cancer research, where aberrant Ras signaling is often implicated.
The scientific importance of the RASA3 Gene Knockout Cell Lines is underscored by their broad applications in both basic and applied research. They serve as invaluable tools for drug discovery, especially in exploring therapeutic targets related to Ras signaling pathways in various malignancies. Additionally, the lines support translational studies aimed at understanding RASA3's role in genetic disorders, offering a comprehensive platform for pharmacological testing and gene therapy approaches.
What sets these cell lines apart from alternatives is their specificity and reliability. Each line is thoroughly validated for consistent gene knockout performance, ensuring reproducibility of results across experiments. The user-friendly protocols provide researchers an accessible route to generating meaningful data with reduced experimental variability. Moreover, these cell lines are optimized for various applications, including high-throughput screening and functional assays.
In today’s rapidly evolving research landscape, RASA3 Gene Knockout Cell Lines present an essential resource for scientists aiming to unravel the complexities of signal transduction and its implications in health and disease. Our company specializes in providing cutting-edge cellular models and genetic tools that empower researchers to achieve groundbreaking discoveries. By choosing our RASA3 Gene Knockout Cell Lines, you invest in a future of scientific advancement and innovation, backed by our commitment to quality and expertise.
Please note that all services are for research use only. Not intended for any clinical use.
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