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RAB33B Knockout Cell Lines

Gene: RAB33B

Official Full Name: RAB33B, member RAS oncogene familyprovided by HGNC

Gene Summary: This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit effector proteins in the GTP-bound state and inactive cytosolic proteins when in a GDP-bound state. The protein encoded by this gene is ubiquitously expressed and has been implicated in Golgi to endoplasmic reticulum cycling of Golgi enzymes. In addition, this protein regulates Golgi homeostasis and coordinates intra-Golgi retrograde trafficking. Allelic variants in this gene have been associated with Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 2, which are autosomal recessive spondyloepimetaphyseal dysplasias characterized by skeletal abnormalities. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06996 RAB33B Knockout cell line (HeLa) Human RAB33B 1:3~1:6 Negative Online Inquiry
KO06997 RAB33B Knockout cell line (HCT 116) Human RAB33B 1:2~1:4 Negative Online Inquiry
KO06998 RAB33B Knockout cell line (HEK293) Human RAB33B 1:3~1:6 Negative Online Inquiry
KO06999 RAB33B Knockout cell line (A549) Human RAB33B 1:3~1:4 Negative Online Inquiry

Background

RAB33B Gene Knockout Cell Lines are genetically engineered cells specifically designed to lack the expression of the RAB33B gene, a member of the Rab GTPase family known to play a crucial role in membrane trafficking and intracellular transport processes. These cell lines serve as powerful tools for researchers aiming to elucidate the biological functions of RAB33B and its implications in various cellular mechanisms.

The primary function of the RAB33B Gene Knockout Cell Lines is to enable the study of cellular pathways that are influenced by the absence of RAB33B. Without this gene, researchers can investigate alterations in endosomal and autophagic processes, leading to insights into conditions such as neurodegenerative diseases and cancers where membrane trafficking is disrupted. The knockout mechanism ensures the effective downregulation of RAB33B expression, facilitating clear and reproducible experimental outcomes.

The scientific importance of these cell lines is underscored by their applications in both basic and translational research. RAB33B knockouts can provide valuable insights into disease mechanisms, potentially offering pathways for therapeutic intervention. In clinical settings, understanding RAB33B might unveil novel biomarkers or treatment targets that appear in diseases linked with dysfunctional intracellular transport.

What sets RAB33B Gene Knockout Cell Lines apart from alternative models is their precision and reliability. Unlike pharmacological inhibitors or transient transfection methods, these knockout lines provide a stable genetic modification that ensures consistent expression levels across experiments, thereby minimizing variability. This stability is vital for reproducibility, allowing researchers to draw more accurate conclusions.

For researchers and clinicians alike, the value of RAB33B Gene Knockout Cell Lines extends beyond mere experimentation; they are a reliable foundation for groundbreaking insights in molecular biology and disease research. Through the use of these cell lines, users can seek to push the boundaries of scientific knowledge and contribute to advancements in medical science.

Our company is committed to providing high-quality, innovative biological products that support the scientific community in its quest for discovery. With extensive expertise in genetic engineering and cell line development, we guarantee reliable products that empower researchers to achieve their goals efficiently.

Please note that all services are for research use only. Not intended for any clinical use.

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