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RAB10 Knockout Cell Lines

Gene: RAB10

Official Full Name: RAB10, member RAS oncogene familyprovided by HGNC

Gene Summary: RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07409 RAB10 Knockout cell line (HeLa) Human RAB10 1:3~1:6 Negative Online Inquiry
KO07410 RAB10 Knockout cell line (HCT 116) Human RAB10 1:2~1:4 Negative Online Inquiry
KO07411 RAB10 Knockout cell line (HEK293) Human RAB10 1:3~1:6 Negative Online Inquiry
KO07412 RAB10 Knockout cell line (A549) Human RAB10 1:3~1:4 Negative Online Inquiry

Background

RAB10 Gene Knockout Cell Lines are engineered cellular models designed to specifically disrupt the expression of the RAB10 gene, a member of the RAB GTPase family known to play critical roles in intracellular vesicle transport and membrane trafficking. By utilizing CRISPR-Cas9 technology, these cell lines provide a reliable platform for elucidating the functions of RAB10 in various biological processes, making them invaluable tools for both basic research and therapeutic development.

The key function of RAB10 involves its participation in endosomal trafficking and glucose homeostasis, particularly in the context of insulin signaling. By employing the RAB10 knockout cell lines, researchers can elucidate the molecular pathways influenced by RAB10 and investigate the consequences of its loss on cellular metabolism, signaling pathways, and disease models, such as obesity and diabetes. This capability aids in the understanding of the broader implications of RAB GTPases in cellular function and human pathology.

Scientifically, RAB10 Gene Knockout Cell Lines are pivotal in providing insights into diseases associated with impaired vesicular transport, revealing novel targets for therapeutic intervention. In clinical settings, such models can accelerate drug discovery processes and foster the development of personalized medicine approaches by enabling the identification of biomarkers and the evaluation of therapeutic efficacy.

One significant advantage of our RAB10 Gene Knockout Cell Lines compared to other available models is the precision and reproducibility afforded by our optimized CRISPR-Cas9 knockout process, which ensures high-specificity in gene editing, minimizing off-target effects. Furthermore, these cell lines are extensively characterized to provide users with reliable and consistent results, which is essential for high-quality research.

For researchers and clinicians focused on the molecular underpinnings of cell signaling and disease, RAB10 Gene Knockout Cell Lines are an indispensable asset. They empower scientific investigations aimed at translating basic research findings into viable therapeutic strategies that can address urgent health challenges.

Our company possesses extensive expertise in cellular engineering and genetic manipulation, delivering high-quality biological products that enhance research capabilities and contribute to advancing scientific knowledge in the field. With a commitment to innovation and excellence, we aim to support the scientific community in exploring the complexities of cellular behavior through our premium products.

Please note that all services are for research use only. Not intended for any clinical use.

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