Gene: PYROXD1
Official Full Name: pyridine nucleotide-disulphide oxidoreductase domain 1provided by HGNC
Gene Summary: This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other proteins. The encoded protein belongs to the class I pyridine nucleotide-disulphide oxidoreductase family but lacks the C-terminal dimerization domain found in other family members and instead has a C-terminal nitrile reductase domain. It localizes to the nucleus and to striated sarcomeric compartments. Naturally occurring mutations in this gene cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. A pseudogene of this gene has been defined on chromosome 11. [provided by RefSeq, Apr 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14776 | PYROXD1 Knockout cell line (HeLa) | Human | PYROXD1 | 1:3~1:6 | Negative | Online Inquiry |
KO14777 | PYROXD1 Knockout cell line (HCT 116) | Human | PYROXD1 | 1:2~1:4 | Negative | Online Inquiry |
KO14778 | PYROXD1 Knockout cell line (HEK293) | Human | PYROXD1 | 1:3~1:6 | Negative | Online Inquiry |
PYROXD1 Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the study of the PYROXD1 gene, which is implicated in various cellular processes, including oxidative stress response and mitochondrial function. Through the application of CRISPR/Cas9 technology, these cell lines feature targeted deletions of the PYROXD1 gene, allowing researchers to observe the consequences of its absence in a controlled environment.
The primary function of these knockout cell lines is to serve as a model system for investigating the biological roles of PYROXD1. By analyzing the phenotypic changes and signaling pathways impacted by the loss of this gene, scientists can elucidate its contributions to cellular metabolism, apoptosis, and disease mechanisms, particularly in the context of neurodegenerative disorders and cancer pathogenesis. This offers a critical platform for stress-response studies and novel therapeutic development.
The scientific importance of PYROXD1 Gene Knockout Cell Lines extends to both research and clinical settings; they provide insights into the correlation between PYROXD1 loss and various pathologies, enabling the identification of potential biomarkers and therapeutic targets. Moreover, these models allow for high-throughput screening of compounds that may restore function or mimic PYROXD1 activity, thus accelerating drug discovery processes.
What sets these cell lines apart from traditional knockout models is their precise gene editing, which ensures reproducibility and reliability across experiments. Additionally, they are validated through rigorous quality control measures to ensure consistent performance. This precision offers a compelling advantage for researchers seeking to derive insightful data for their studies.
For researchers, clinicians, and biotech companies, PYROXD1 Gene Knockout Cell Lines hold significant value as they foster a deeper understanding of key biological processes and disease mechanisms. By using these advanced models, researchers can facilitate breakthroughs that translate into clinical applications, potentially leading to improved patient outcomes.
Our company is committed to providing high-quality, innovative biological products, and with extensive experience in gene editing technologies, we ensure that our PYROXD1 Gene Knockout Cell Lines adhere to the highest scientific standards, empowering researchers to drive discoveries with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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