Gene: PUS7
Official Full Name: pseudouridine synthase 7provided by HGNC
Gene Summary: Enables enzyme binding activity and tRNA pseudouridine(13) synthase activity. Involved in several processes, including pseudouridine synthesis; regulation of hematopoietic stem cell differentiation; and regulation of mesoderm development. Is active in nucleus. Implicated in intellectual developmental disorder with abnormal behavior, microcephaly, and short stature. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01330 | PUS7 Knockout cell line (HeLa) | Human | PUS7 | 1:3~1:6 | Negative | Online Inquiry |
KO06152 | PUS7 Knockout cell line (HCT 116) | Human | PUS7 | 1:2~1:4 | Negative | Online Inquiry |
KO06153 | PUS7 Knockout cell line (HEK293) | Human | PUS7 | 1:3~1:6 | Negative | Online Inquiry |
KO06154 | PUS7 Knockout cell line (A549) | Human | PUS7 | 1:3~1:4 | Negative | Online Inquiry |
PUS7 Gene Knockout Cell Lines are sophisticated cellular models engineered to lack the expression of the PUS7 gene, which encodes a protein known to play a critical role in tRNA modification. These cell lines are developed through precise gene-editing techniques, such as CRISPR-Cas9, which enable researchers to elucidate the specific biological functions associated with PUS7, including its involvement in ribonucleoprotein complex assembly and post-transcriptional regulation of gene expression.
The key mechanism behind the PUS7 Gene Knockout Cell Lines lies in their ability to facilitate the study of PUS7's role in cellular processes. By observing these modified cell lines, researchers can better understand how the absence of PUS7 affects tRNA stability, translation efficiency, and overall cellular health. This knowledge is vital for advancing our comprehension of genetic diseases related to tRNA dysfunction, as well as for investigating broader implications in cellular metabolism and stress responses.
Scientifically, these cell lines hold considerable importance in both basic and applied research. They are valuable in pharmacological studies and drug development, helping to identify potential therapeutic targets related to diseases such as cancer and neurological disorders. Moreover, they serve as powerful tools in the field of molecular biology, enhancing the understanding of gene function through the manipulation of the genetic landscape.
What sets PUS7 Gene Knockout Cell Lines apart from other genetic models is their precise gene editing, ensuring reliable results and reproducibility in experiments. Their use in research can streamline the pathway to discovering novel treatments, offering researchers exceptional clarity into the cascading effects of gene loss on cellular pathways.
With an unwavering commitment to quality, our company leverages cutting-edge technology and expert knowledge in genetic engineering, providing researchers and clinicians with products that not only enhance research capabilities but also pave the way for innovative biological solutions. As a trusted provider in the field, we excel at delivering high-performance biological products designed to meet the intricate needs of contemporary scientific inquiry.
Please note that all services are for research use only. Not intended for any clinical use.
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