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PTS Knockout Cell Lines

Gene: PTS

Official Full Name: 6-pyruvoyltetrahydropterin synthaseprovided by HGNC

Gene Summary: The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35774 PTS Knockout cell line (HeLa) Human PTS 1:3~1:6 Negative Online Inquiry
KO35775 PTS Knockout cell line (HCT 116) Human PTS 1:2~1:4 Negative Online Inquiry
KO35776 PTS Knockout cell line (HEK293) Human PTS 1:3~1:6 Negative Online Inquiry
KO35777 PTS Knockout cell line (A549) Human PTS 1:3~1:4 Negative Online Inquiry

Background

PTS Gene Knockout Cell Lines are sophisticated biological tools designed for the precise study of gene function and its implications in cellular processes. These cell lines are meticulously engineered to harbor targeted deletions of the PTS gene, which encodes for the enzyme involved in the metabolism of various substrates, impacting cellular energy production and signaling pathways. By eliminating the functional expression of the PTS gene, researchers can interrogate the biological consequences of gene loss, thereby enhancing their understanding of disease mechanisms and potential therapeutic interventions.

The core mechanism of PTS Gene Knockout Cell Lines involves the use of CRISPR-Cas9 technology, which allows for specific and efficient editing of the genome, leading to the creation of stable cell lines that lack PTS gene expression. This innovation enables scientists to conduct experiments that elucidate the role of the PTS gene in metabolic pathways, drug responses, and the overall cellular environment. Consequently, these knockout cell lines are invaluable in both research and clinical settings, facilitating the development of targeted therapies and the study of genetic disorders.

A noteworthy advantage of PTS Gene Knockout Cell Lines is their high specificity and reliability in gene disruption compared to traditional methods, such as RNA interference or random mutagenesis. Additionally, they provide a reproducible model system that can be readily used across different experiments, drastically reducing variability and enhancing experimental precision. This makes them particularly appealing for researchers aiming for conclusive results in their studies.

Furthermore, the ability to utilize these knockout lines in screening applications holds significant promise for drug discovery and regenerative medicine. As various fields increasingly rely on tailored therapeutic strategies, PTS Gene Knockout Cell Lines serve as a critical asset for both academic and commercial laboratories, enhancing our understanding of gene function and advancing personalized medicine approaches.

At [Your Company Name], we pride ourselves on our extensive experience in biotechnology and commitment to providing high-quality, innovative tools for the scientific community. Our PTS Gene Knockout Cell Lines are a testament to this dedication, ensuring researchers have access to cutting-edge resources that drive discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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