Gene: PTPRR
Official Full Name: protein tyrosine phosphatase receptor type Rprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10531 | PTPRR Knockout cell line (HeLa) | Human | PTPRR | 1:3~1:6 | Negative | Online Inquiry |
PTPRR Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to ablate the protein tyrosine phosphatase, receptor type R (PTPRR), which plays a pivotal role in various cellular processes, including signal transduction and cellular communication. These cell lines facilitate the study of PTPRR function by providing researchers with a model to investigate the consequences of its absence on cellular behavior and metabolism.
The key function of PTPRR involves modulation of signaling pathways through dephosphorylation of tyrosine residues on target proteins, thereby influencing processes such as cell growth, differentiation, and apoptosis. By employing CRISPR/Cas9 technology, our knockout cell lines feature precise edits to the PTPRR gene, allowing for the efficient evaluation of the gene's role in disease mechanisms, particularly in cancer research and neurobiology. The absence of PTPRR in these cell lines enables researchers to elucidate pathways that are upregulated or downregulated in response to its loss, thereby shedding light on potential therapeutic targets.
The scientific significance of PTPRR Gene Knockout Cell Lines extends to both fundamental and applied research. In clinical settings, understanding the regulatory mechanisms of PTPRR could contribute to the development of targeted therapies for cancers where PTPRR activity is altered. Moreover, these cell lines are invaluable for drug discovery and development, providing an essential model for screening pharmacological agents.
A distinct advantage of our PTPRR Gene Knockout Cell Lines is their high specificity and confirmed genetic integrity, ensuring reproducibility and reliability in experimental outcomes. Comparatively, alternative models may lack the precision or comprehensive characterization we offer, potentially leading to ambiguous results. By focusing on delivering exceptional genetic models, we stand out as a provider of advanced cellular tools for biomedical research.
This product embodies our commitment to supporting researchers and clinicians seeking to advance their understanding of complex biological systems and discover innovative therapeutic strategies. With a robust portfolio of genetically modified models and a team of experts in genetic analysis, we offer unparalleled resources for cutting-edge research.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.