Gene: PTPRH
Official Full Name: protein tyrosine phosphatase receptor type Hprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35799 | PTPRH Knockout cell line (HCT 116) | Human | PTPRH | 1:2~1:4 | Negative | Online Inquiry |
KO35800 | PTPRH Knockout cell line (A549) | Human | PTPRH | 1:3~1:4 | Negative | Online Inquiry |
PTPRH Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the PTPRH gene, which encodes a member of the protein tyrosine phosphatase family. These cell lines facilitate the investigation of the biological role of PTPRH in cellular processes such as signal transduction, cell growth, differentiation, and disease pathogenesis. The knockout of this gene is achieved through advanced genome editing techniques, most commonly CRISPR-Cas9, ensuring precise modification without off-target effects.
The primary function of the PTPRH Gene Knockout Cell Lines lies in their ability to serve as a powerful tool for researchers aiming to elucidate the specific functions of PTPRH in various physiological and pathological contexts. By examining how these cells respond to stimuli or during interactions with other cell types, scientists can derive significant insights into the signaling pathways influenced by PTPRH, contributing to a greater understanding of diseases where dysregulated tyrosine phosphorylation plays a key role, such as cancer and autoimmune disorders.
In research and clinical settings, these knockout cell lines are invaluable for drug discovery, biomarker identification, and understanding the underlying mechanisms of disease. Since PTPRH has been implicated in both solid tumors and hematological malignancies, utilizing these cell lines can unveil potential therapeutic targets and facilitate the development of novel treatments.
One of the specific advantages of our PTPRH Gene Knockout Cell Lines is their versatility for high-throughput screening applications, allowing researchers to efficiently assess the impact of pharmacological agents on cell behavior in a controlled environment. Additionally, our cell lines are rigorously validated for consistent performance and reproducibility, meeting the stringent quality standards that researchers require.
Choosing our PTPRH Gene Knockout Cell Lines enables researchers and clinicians to leverage the latest advancements in genetic engineering for significant breakthroughs in understanding cellular functions and disease mechanisms. With our team of experienced professionals and commitment to innovation, we provide high-quality biological products that support the path to scientific discovery and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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