Gene: PTPN4
Official Full Name: protein tyrosine phosphatase non-receptor type 4provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35805 | PTPN4 Knockout cell line (HeLa) | Human | PTPN4 | 1:3~1:6 | Negative | Online Inquiry |
KO35806 | PTPN4 Knockout cell line (HCT 116) | Human | PTPN4 | 1:2~1:4 | Negative | Online Inquiry |
KO35807 | PTPN4 Knockout cell line (HEK293) | Human | PTPN4 | 1:3~1:6 | Negative | Online Inquiry |
KO35808 | PTPN4 Knockout cell line (A549) | Human | PTPN4 | 1:3~1:4 | Negative | Online Inquiry |
PTPN4 Gene Knockout Cell Lines refer to a set of genetically modified cell lines in which the PTPN4 gene, responsible for encoding the protein tyrosine phosphatase non-receptor type 4, has been selectively disrupted. This knockout approach allows researchers to investigate the functional consequences of PTPN4 loss, providing critical insights into its role in various cellular processes, such as signal transduction and cell proliferation.
The primary function of these cell lines is to facilitate studies on the molecular mechanisms underlying several pathophysiological conditions. PTPN4 is implicated in multiple cellular signaling pathways, particularly those related to development, immunity, and cancer. By manipulating this gene, researchers can elucidate its contributions to oncogenesis, cell adhesion, and other biological phenomena, thus advancing our understanding of disease mechanisms.
The scientific importance of PTPN4 Gene Knockout Cell Lines lies in their versatility and applicability across diverse areas of research. In cancer research, they enable the exploration of tumor suppressor functions and resistance mechanisms. Additionally, these cell lines are invaluable for drug discovery efforts, where understanding the PTPN4 signaling pathway could lead to the development of targeted therapies.
Unique advantages of PTPN4 Gene Knockout Cell Lines over traditional cell models include their precise gene disruption, which provides a more accurate representation of in vivo conditions compared to transient knockdown methods. This specificity is crucial for reproducibility and reliability in experiments, making these cell lines an optimal choice for rigorous scientific investigation.
For researchers and clinicians looking to deepen their understanding of complex biological systems or seek novel therapeutic targets, PTPN4 Gene Knockout Cell Lines offer an unprecedented opportunity to innovate and advance the frontiers of biomedical research. With our commitment to quality and innovation, our company is at the forefront of providing cutting-edge genetic tools to the scientific community, empowering researchers to unlock new discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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