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PTP4A3 Knockout Cell Lines

Gene: PTP4A3

Official Full Name: protein tyrosine phosphatase 4A3provided by HGNC

Gene Summary: This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06109 PTP4A3 Knockout cell line (HCT 116) Human PTP4A3 1:2~1:4 Negative Online Inquiry
KO06110 PTP4A3 Knockout cell line (HEK293) Human PTP4A3 1:3~1:6 Negative Online Inquiry
KO06111 PTP4A3 Knockout cell line (A549) Human PTP4A3 1:3~1:4 Negative Online Inquiry

Background

PTP4A3 Gene Knockout Cell Lines are genetically engineered cell lines that have had the PTP4A3 gene specifically inactivated through precise gene editing techniques such as CRISPR-Cas9. PTP4A3, also known as Protein Tyrosine Phosphatase 4A3, is implicated in several cellular processes, including the regulation of cell growth, differentiation, and migration. The knockout of this gene provides researchers with a powerful tool to study its biological functions and the implications of its dysregulation in various diseases, particularly cancer.

These cell lines operate by lacking the PTP4A3 protein, allowing for the observation of phenotypic changes when this critical signaling pathway is disrupted. By using these knockout cell lines, researchers can investigate the role of PTP4A3 in tumor progression and metastasis, assess the impact on cell signaling cascades, and explore potential therapeutic targets. In clinical research settings, understanding the PTP4A3 gene's role could lead to novel biomarker identification and the development of intervention strategies for diseases characterized by aberrant PTP4A3 signaling.

The unique advantage of using PTP4A3 Gene Knockout Cell Lines lies in their specificity and reliability, enabling precise elucidation of PTP4A3's functions compared to alternative methods like pharmacological inhibition, which may provide off-target effects. Additionally, these cell lines are crucial for high-throughput screening applications, allowing researchers to efficiently evaluate compounds that could modulate PTP4A3 activity.

For researchers and clinicians focused on cancer biology and therapeutic development, the PTP4A3 Gene Knockout Cell Lines represent a cutting-edge resource that facilitates innovative experimental designs. Our company prides itself on delivering high-quality biological products and has a strong commitment to supporting the scientific community through robust research tools and resources designed with precision and reliability.

Please note that all services are for research use only. Not intended for any clinical use.

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