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PTCH2 Knockout Cell Lines

Gene: PTCH2

Official Full Name: patched 2provided by HGNC

Gene Summary: This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10024 PTCH2 Knockout cell line (HEK293) Human PTCH2 1:3~1:6 Negative Online Inquiry

Background

PTCH2 Gene Knockout Cell Lines are genetically modified cell lines engineered to selectively deactivate the PTCH2 gene, a critical component of the Hedgehog signaling pathway that plays a significant role in cellular communication and development. This product allows researchers to study the functional consequences of PTCH2 gene loss and investigate its involvement in various biological processes, including tumorigenesis and developmental abnormalities.

These knockout cell lines operate on the principle of CRISPR-Cas9 genome editing technology, which provides a precise and efficient method for targeted gene disruption. By eliminating the PTCH2 gene, these cell lines enable scientists to dissect the molecular pathways influenced by Hedgehog signaling, facilitating the identification of potential therapeutic targets for cancers and genetic disorders associated with aberrant signaling.

The scientific importance of PTCH2 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. Researchers utilize these cell lines to explore the pathway's contribution to disease states, paving the way for the development of innovative treatment strategies. In clinical settings, understanding how PTCH2 influences disease mechanisms can aid in the personalization of therapies aimed at modulating the Hedgehog pathway.

Advantages of our PTCH2 Gene Knockout Cell Lines include their validated performance and reproducibility. Unlike some alternatives, which may offer incomplete gene knockout or lack comprehensive characterizations, our product guarantees a complete and stable deletion of the PTCH2 gene. This robust reliability empowers researchers to generate consistent and reproducible results, a crucial factor in experimental design.

In today’s competitive research landscape, the availability of high-quality, gene knockout models is invaluable. By choosing our PTCH2 Gene Knockout Cell Lines, researchers and clinicians gain access to a tool that not only enhances their understanding of complex biological systems but also drives innovation in their fields. Our company prides itself on a commitment to excellence in biological products, backed by years of expertise and a dedicated approach to supporting the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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