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PSMF1 Knockout Cell Lines

Gene: PSMF1

Official Full Name: proteasome inhibitor subunit 1provided by HGNC

Gene Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33187 PSMF1 Knockout cell line (HeLa) Human PSMF1 1:3~1:6 Negative Online Inquiry
KO33188 PSMF1 Knockout cell line (HCT 116) Human PSMF1 1:2~1:4 Negative Online Inquiry
KO33189 PSMF1 Knockout cell line (HEK293) Human PSMF1 1:3~1:6 Negative Online Inquiry
KO33190 PSMF1 Knockout cell line (A549) Human PSMF1 1:3~1:4 Negative Online Inquiry

Background

PSMF1 Gene Knockout Cell Lines are genetically modified cellular models featuring a targeted disruption of the PSMF1 gene, which encodes the proteasome inhibitor protein involved in cellular degradation processes. This innovative product allows researchers to study the precise physiological and pathological roles of PSMF1 in various cellular contexts, particularly its influence on protein homeostasis and cellular stress responses.

The key functionality of PSMF1 Gene Knockout Cell Lines lies in their ability to facilitate the investigation of cellular mechanisms underpinning proteostasis and signal transduction. By removing the PSMF1 gene, these cell lines enable scientists to observe the effects of its absence on the proteasomal degradation pathway, thus providing insights into how alterations in protein turnover can lead to various diseases, including cancer and neurodegenerative disorders. Researchers can utilize these cell lines to screen potential therapeutic compounds and develop novel interventions aimed at modulating proteasome activity.

From a scientific perspective, PSMF1 Gene Knockout Cell Lines represent a powerful tool for both basic research and translational applications. Their utility extends to pharmacological studies, biomarker discovery, and the development of precision medicine strategies. Compared to traditional wild-type cell lines, the knockout variants deliver a clear advantage by allowing for the direct observation of PSMF1 function without the confounding effects posed by the endogenous gene.

For researchers and clinicians alike, these cell lines offer significant value, supporting investigations into disease mechanisms and treatment options with unparalleled precision. The ability to manipulate specific gene functions enhances experimental rigour while significantly contributing to the understanding of complex biological systems.

Our company specializes in the development and provision of high-quality genetic tools, aiming to empower researchers in their quest for scientific knowledge and innovations. With a commitment to excellence and reliability, our PSMF1 Gene Knockout Cell Lines stand out as a vital resource for advancing biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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