Gene: PRUNE2
Official Full Name: prune homolog 2 with BCH domainprovided by HGNC
Gene Summary: The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14826 | PRUNE2 Knockout cell line (HeLa) | Human | PRUNE2 | 1:3~1:6 | Negative | Online Inquiry |
KO14827 | PRUNE2 Knockout cell line (HEK293) | Human | PRUNE2 | 1:3~1:6 | Negative | Online Inquiry |
PRUNE2 Gene Knockout Cell Lines are specialized cellular models designed for the investigation of the PRUNE2 gene's function in various biological processes. By employing CRISPR/Cas9 technology, these cell lines have been engineered to disrupt the PRUNE2 gene, creating a powerful tool for researchers to study its role in cellular pathways, disease mechanisms, and therapeutic resistance.
The key functionality of PRUNE2 Gene Knockout Cell Lines lies in their ability to simulate specific genetic conditions while maintaining the integrity of other cellular functions. This allows for a detailed analysis of gene interactions and phenotypic outcomes arising from the loss of PRUNE2 expression. The mechanism of action involves targeted alterations in the genomic DNA, effectively leading to the cessation of PRUNE2 protein production, which can subsequently influence downstream signaling pathways and cellular responses.
From a scientific standpoint, these knockout cell lines are invaluable in both research and clinical settings. They facilitate the elucidation of the PRUNE2 gene's involvement in cancer progression, neurodegenerative disorders, and other pathologies, thereby offering insights that could lead to novel therapeutic strategies. Furthermore, their use in drug screening and biomarker discovery can hasten the development of targeted therapies.
Compared to traditional cell lines or unspecific knockout models, PRUNE2 Gene Knockout Cell Lines provide researchers with precise genetic modifications and reproducible results. This specificity enhances the reliability of experimental outcomes, making them more relevant to human health applications.
For researchers and clinicians dedicated to advancing our understanding of gene function and disease mechanisms, PRUNE2 Gene Knockout Cell Lines offer a unique and potent resource. Their capacity to bridge fundamental research with translational applications underscores their importance in the ongoing quest for medical breakthroughs.
Our company is committed to providing high-quality biological products, grounded in rigorous scientific principles and innovative methodologies, to empower researchers in their endeavors towards discovery and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.