Gene: PRSS12
Official Full Name: serine protease 12provided by HGNC
Gene Summary: This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34128 | PRSS12 Knockout cell line (HeLa) | Human | PRSS12 | 1:3~1:6 | Negative | Online Inquiry |
KO34129 | PRSS12 Knockout cell line (HCT 116) | Human | PRSS12 | 1:2~1:4 | Negative | Online Inquiry |
KO34130 | PRSS12 Knockout cell line (HEK293) | Human | PRSS12 | 1:3~1:6 | Negative | Online Inquiry |
PRSS12 Gene Knockout Cell Lines are specialized model systems engineered to facilitate the study of the protease serine 12 (PRSS12) gene. PRSS12 encodes for a serine protease that plays a pivotal role in various physiological processes, such as neuronal development and tissue remodeling. By utilizing these knockout cell lines, researchers can effectively investigate the functional implications of PRSS12 absence at both cellular and molecular levels.
These cell lines operate by employing the CRISPR-Cas9 gene-editing technology to create specific, heritable modifications of the PRSS12 gene. The resulting knockout cells exhibit a complete loss of PRSS12 gene expression, allowing for comprehensive analyses of its role in signaling pathways, cellular motility, and disease progression. This functional dissection is essential for understanding PRSS12's contribution in contexts such as cancer biology and neurological disorders.
The scientific importance of PRSS12 Gene Knockout Cell Lines lies in their ability to serve as robust tools for elucidating the molecular underpinnings of diseases where PRSS12 is implicated. These models can be employed in academic research, drug development, and even therapeutic investigations, providing invaluable insights that advance the field of molecular biology and translational medicine.
Compared to traditional approaches, such as overexpression systems or RNA interference, the use of knockout cell lines presents distinct advantages. They allow for the complete and permanent loss of gene function, thereby minimizing off-target effects commonly associated with knockdown methods. Furthermore, the genetic stability of these lines fosters reproducibility in experimental results, a crucial factor in robust scientific research.
For researchers and clinicians alike, the value of PRSS12 Gene Knockout Cell Lines cannot be overstated; they empower users to dissect intricate biological pathways with precision, ultimately paving the way for breakthroughs in therapeutic strategies. Our company prides itself on advanced cellular models and gene editing technologies, ensuring that our products support the highest level of scientific inquiry and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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