Gene: PRRG2
Official Full Name: proline rich and Gla domain 2provided by HGNC
Gene Summary: The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35873 | PRRG2 Knockout cell line (HCT 116) | Human | PRRG2 | 1:2~1:4 | Negative | Online Inquiry |
KO35874 | PRRG2 Knockout cell line (HEK293) | Human | PRRG2 | 1:3~1:6 | Negative | Online Inquiry |
KO35875 | PRRG2 Knockout cell line (A549) | Human | PRRG2 | 1:3~1:4 | Negative | Online Inquiry |
PRRG2 Gene Knockout Cell Lines are specialized cellular models engineered to specifically disable the PRRG2 gene, which encodes for the proline-rich protein that plays critical roles in cellular processes including cell cycle regulation, differentiation, and apoptosis. By utilizing CRISPR/Cas9 gene editing technology, these cell lines provide a robust platform for studying the functional consequences of PRRG2 loss in various biological contexts, such as cancer biology, neurodevelopmental disorders, and other pathophysiological conditions.
The significant mechanism underlying the functionality of these knockout cell lines lies in their ability to allow researchers to investigate the effects of PRRG2 gene disruption on cellular behavior and gene expression profiles. This transformation creates a unique opportunity to elucidate the pathways and molecular interactions associated with PRRG2, offering insights into its role within specific signaling networks or cellular responses to external stimuli.
Scientifically, PRRG2 Gene Knockout Cell Lines are invaluable in both basic and translational research settings. They enable investigators to model diseases more accurately and test potential therapeutic interventions, making them critical assets in drug discovery and development. Their applications also extend to gene therapy and regenerative medicine research, where understanding gene function is paramount.
What sets these cell lines apart from other gene knockout models is their high specificity and reproducibility, providing researchers with consistent and reliable tools for experimental validation. The PRRG2 knockout approach is designed to minimize off-target effects commonly associated with other gene-editing strategies, thus ensuring the integrity of experimental results.
For researchers and clinicians, the value of PRRG2 Gene Knockout Cell Lines is evident in their potential to reveal the intricate roles of the PRRG2 protein in health and disease. By equipping laboratories worldwide with these advanced models, we empower scientists to push the boundaries of knowledge and innovation.
At our company, we pride ourselves on a legacy of excellence in developing high-quality biological products, backed by a team of experienced scientists dedicated to advancing research and improving health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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