Gene: PRRC2A
Official Full Name: proline rich coiled-coil 2Aprovided by HGNC
Gene Summary: A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34388 | PRRC2A Knockout cell line (HeLa) | Human | PRRC2A | 1:3~1:6 | Negative | Online Inquiry |
KO34389 | PRRC2A Knockout cell line (HCT 116) | Human | PRRC2A | 1:2~1:4 | Negative | Online Inquiry |
KO34390 | PRRC2A Knockout cell line (HEK293) | Human | PRRC2A | 1:3~1:6 | Negative | Online Inquiry |
KO34391 | PRRC2A Knockout cell line (A549) | Human | PRRC2A | 1:3~1:4 | Negative | Online Inquiry |
PRRC2A Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the PRRC2A gene's functional roles in various biological processes. These cell lines have undergone targeted gene editing to disrupt PRRC2A expression, thereby enabling researchers to investigate the consequences of its absence on cellular behavior, signaling pathways, and gene expression profiles.
The key functionality of these knockout cell lines lies in their ability to mimic gene loss-of-function scenarios, allowing scientists to elucidate PRRC2A's involvement in processes such as RNA splicing, cellular proliferation, and regulation of gene transcription. The mechanism of action is rooted in CRISPR/Cas9 technology, which provides a precise, efficient method of gene editing. This approach ensures that researchers can produce reliable and reproducible data regarding the biological roles of PRRC2A in both normal physiology and pathological conditions.
The scientific importance of PRRC2A Gene Knockout Cell Lines extends to their applications in cancer research, neurobiology, and developmental biology, where PRRC2A has been implicated. By using these models, researchers can develop novel therapeutic strategies, screen for potential drug candidates, or investigate gene-environment interactions in diseases associated with PRRC2A dysregulation.
What sets these knockout cell lines apart from alternatives is their high specificity and efficiency, minimizing off-target effects and thereby ensuring that experimental results are robust. Additionally, the availability of well-characterized cell lines reduces the time and resources typically required for generating new models, accelerating the pace of research.
For researchers and clinicians alike, the value of PRRC2A Gene Knockout Cell Lines is evident in their potential to advance understanding of gene function and its impact on health and disease. By integrating these cell lines into experimental workflows, users can obtain critical insights that fully leverage modern molecular biology techniques.
Our company prides itself on its expertise in genetic engineering and cell line development. We are dedicated to providing high-quality biological products that empower the scientific community to drive innovation and discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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