Gene: PROZ
Official Full Name: protein Z, vitamin K dependent plasma glycoproteinprovided by HGNC
Gene Summary: This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33778 | PROZ Knockout cell line (HEK293) | Human | PROZ | 1:3~1:6 | Negative | Online Inquiry |
PROZ Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of the PROZ gene's role in biological processes and disease mechanisms. These cell lines are generated through the CRISPR-Cas9 genome editing technology, which allows for precise alterations at the genetic level, effectively rendering the PROZ gene non-functional. This process ensures that researchers can observe the impact of gene loss on cellular function, pathway regulation, and overall physiology.
The primary function of the PROZ Gene Knockout Cell Lines is to provide a platform for investigating the biological significance of PROZ in various contexts, including hematology and inflammatory responses. By utilizing these knockout models, scientists can elucidate the pathways driven by PROZ and explore its implications in disease etiologies, potentially leading to the identification of novel therapeutic targets.
In the realm of research and clinical applications, these knockout cell lines are of paramount importance. They serve as invaluable tools in drug discovery, enabling researchers to screen potential pharmaceutical compounds that may modulate the function of pathways influenced by the PROZ gene. Furthermore, their application in preclinical studies can offer insights into the efficacy and safety of new therapies aimed at conditions where PROZ plays a pivotal role.
What distinguishes PROZ Gene Knockout Cell Lines from traditional cell models is their specificity and the advanced gene-editing technology employed in their development. Unlike conventional knockout methods, which may yield off-target effects or incomplete gene silencing, the CRISPR-Cas9 technique allows for targeted, efficient, and reproducible gene disruption. This precision not only enhances the reliability of experimental outcomes but also reduces variability in research findings.
For researchers, clinicians, and pharmaceutical developers dedicated to advancing our understanding of genetic pathways and improving patient outcomes, PROZ Gene Knockout Cell Lines represent a significant advancement in experimental biology. Their availability can facilitate a deeper exploration into gene functions and accelerate the translation of scientific discoveries into clinical applications.
At [Your Company Name], our expertise in genetic engineering and commitment to quality ensure that each PROZ Gene Knockout Cell Line meets rigorous standards of performance and reliability. We strive to empower the scientific community with innovative tools that pave the way for breakthroughs in gene-related research.
Please note that all services are for research use only. Not intended for any clinical use.
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