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PRKCZ Knockout Cell Lines

Gene: PRKCZ

Official Full Name: protein kinase C zetaprovided by HGNC

Gene Summary: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00168 PRKCZ Knockout cell line (A549) Human PRKCZ 1:3~1:4 Negative Online Inquiry
KO08654 PRKCZ Knockout cell line (HeLa) Human PRKCZ 1:3~1:6 Negative Online Inquiry
KO08655 PRKCZ Knockout cell line (HCT 116) Human PRKCZ 1:2~1:4 Negative Online Inquiry
KO08656 PRKCZ Knockout cell line (HEK293) Human PRKCZ 1:3~1:6 Negative Online Inquiry

Background

PRKCZ Gene Knockout Cell Lines are highly specialized cellular models that have undergone targeted genetic alteration to disrupt the function of the PRKCZ gene, coding for protein kinase C zeta. These cell lines serve as critical tools for investigating the role of PRKCZ in various biological processes, including cell signaling, proliferation, and apoptosis. By knocking out the PRKCZ gene, researchers can more accurately evaluate the functions and molecular pathways influenced by this key kinase, enabling better understanding of its contributions to cellular physiology and pathophysiology.

The mechanism underlying these knockout models is based on advanced gene-editing technologies, such as CRISPR-Cas9 or TALENs, which facilitate precise modifications in the genome. This genetic manipulation not only allows for the assessment of PRKCZ’s role in cell function and disease states but also aids in elucidating the intricate network of signaling pathways that it modulates, particularly in cancer and neurodegeneration research.

The scientific importance of PRKCZ Gene Knockout Cell Lines is significant in both research and clinical contexts. Researchers utilize these models to explore potential therapeutic targets and test the efficacy of new pharmaceuticals that may inhibit or modify PRKCZ signaling. In clinical settings, understanding PRKCZ activity could lead to innovative strategies for treating cancers where this pathway is dysregulated.

One of the distinguishing advantages of our PRKCZ Gene Knockout Cell Lines lies in the precision of the gene-editing approach utilized, which minimizes off-target effects and maximizes the reliability of experimental outcomes compared to older methods. Furthermore, these cell lines come with comprehensive characterization and validation, ensuring that researchers can trust the data generated.

For researchers and clinicians focused on unraveling complex signaling pathways and their implications in diseases, PRKCZ Gene Knockout Cell Lines offer unparalleled value. They provide a robust platform for exploring novel therapeutics and understanding disease mechanisms at a molecular level.

Our company, with its deep commitment to advancing biological research and comprehensive support infrastructure, ensures that you receive high-quality, rigorously validated products that empower your research objectives.

Please note that all services are for research use only. Not intended for any clinical use.

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