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PRKCG Knockout Cell Lines

Gene: PRKCG

Official Full Name: protein kinase C gammaprovided by HGNC

Gene Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10532 PRKCG Knockout cell line (HCT 116) Human PRKCG 1:2~1:4 Negative Online Inquiry
KO10533 PRKCG Knockout cell line (A549) Human PRKCG 1:3~1:4 Negative Online Inquiry

Background

PRKCG Gene Knockout Cell Lines are specialized cellular models engineered to disable the activity of the protein kinase C gamma (PRKCG) gene, a critical component involved in various signaling pathways within cells. These knockout cell lines serve as powerful tools for researchers studying the intricate roles that PRKCG plays in cellular processes such as neuronal signaling, synaptic plasticity, and tumor growth.

The key function of the PRKCG knockout cell lines is their ability to simulate the absence of PRKCG, allowing scientists to observe changes and assess compensatory mechanisms that may occur due to the loss of this gene. The mechanisms at work involve pathway analysis where researchers can evaluate alterations in downstream signaling processes, providing insights into the biological implications of PRKCG’s activity or inactivity. This makes these cell lines invaluable in elucidating the gene's role in neurological disorders and certain cancers.

In research and clinical settings, the PRKCG knockout cell lines have significant importance for drug discovery and development, enabling pharmaceutical companies and academic institutions to screen therapeutic candidates with a focus on PRKCG-related pathways. This capability can lead to innovations in treatment approaches for conditions like epilepsy, mood disorders, and other neurodegenerative diseases.

Compared to other cellular models, the PRKCG gene knockout lines offer a unique advantage in specificity and reliability, ensuring that researchers are working with a pure model that faithfully represents the biological questions at hand. Furthermore, these cell lines are meticulously validated, reducing variability and increasing the reproducibility of experimental results.

For researchers and clinicians, the PRKCG Gene Knockout Cell Lines represent a vital resource for advancing their understanding of complex cellular functions and developing targeted therapies. By leveraging this innovative product, users can contribute to the frontiers of molecular biology and therapeutic development.

Our company specializes in the production and validation of high-quality biological products, ensuring that each offering meets rigorous scientific standards, thereby empowering researchers and clinicians to achieve their goals with confidence and precision.

Please note that all services are for research use only. Not intended for any clinical use.

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