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PRKCD Knockout Cell Lines

Gene: PRKCD

Official Full Name: protein kinase C deltaprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05592 PRKCD Knockout cell line (HeLa) Human PRKCD 1:3~1:6 Negative Online Inquiry
KO05593 PRKCD Knockout cell line (HCT 116) Human PRKCD 1:2~1:4 Negative Online Inquiry
KO05594 PRKCD Knockout cell line (HEK293) Human PRKCD 1:3~1:6 Negative Online Inquiry
KO05595 PRKCD Knockout cell line (A549) Human PRKCD 1:3~1:4 Negative Online Inquiry

Background

PRKCD Gene Knockout Cell Lines are specialized cell culture models created through the targeted disruption of the PRKCD gene, which encodes for Protein Kinase C Delta (PKCδ), a critical regulator of cellular signaling pathways involved in proliferation, differentiation, and apoptosis. These cell lines serve as powerful tools for researchers aiming to understand the implications of PKCδ in various physiological and pathological contexts, including cancer, inflammation, and neurodegenerative disorders.

The knockout of the PRKCD gene leads to a significant decrease in PKCδ protein levels, allowing for the investigation of cellular processes in its absence. The unique mechanism by which these cell lines operate provides invaluable insight into the functional roles of PKCδ, specifically its involvement in modulating stress responses and cell survival pathways. By employing techniques such as CRISPR-Cas9 or RNA interference, researchers can effectively manipulate these cell lines to examine downstream signaling pathways, gene expression profiles, and cellular responses to external stimuli.

The scientific importance of PRKCD Gene Knockout Cell Lines stems from their application in diverse research areas, including cancer biology, where aberrant PKCδ activity is linked to tumor progression, and neuroscience, where it plays roles in synaptic plasticity. These models facilitate the understanding of disease mechanisms and the development of therapeutic interventions.

What sets PRKCD Gene Knockout Cell Lines apart from other cell culture models is their specificity and precision in gene editing. Unlike traditional knockout models that may exhibit off-target effects or residual gene expression, our cell lines provide a robust, highly characterized system that ensures the reliable evaluation of PKCδ functions. This refinement translates to more credible experimental outcomes and encourages more reproducible research findings.

For researchers and clinicians, these knockout cell lines offer the invaluable advantage of elucidating the direct role of PKCδ in cellular phenomena, thereby significantly accelerating the discovery of novel therapeutic targets. Whether it's for drug development, mechanistic studies, or translational research, the versatility of these cell lines positions them as a vital asset in biological research.

Our company stands at the forefront of biological product offerings, specializing in innovative solutions designed for precision research. With a commitment to quality and scientific integrity, we provide products like PRKCD Gene Knockout Cell Lines that empower researchers to advance their work with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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