Gene: PPP1R13B
Official Full Name: protein phosphatase 1 regulatory subunit 13Bprovided by HGNC
Gene Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29353 | PPP1R13B Knockout cell line (HeLa) | Human | PPP1R13B | 1:3~1:6 | Negative | Online Inquiry |
KO29354 | PPP1R13B Knockout cell line (HCT 116) | Human | PPP1R13B | 1:2~1:4 | Negative | Online Inquiry |
KO29355 | PPP1R13B Knockout cell line (HEK293) | Human | PPP1R13B | 1:3~1:6 | Negative | Online Inquiry |
KO29356 | PPP1R13B Knockout cell line (A549) | Human | PPP1R13B | 1:3~1:4 | Negative | Online Inquiry |
PPP1R13B Gene Knockout Cell Lines are genetically modified cell lines that have been specifically designed to study the function of the PPP1R13B gene, which encodes a regulatory protein implicated in various cellular processes, including apoptosis and signal transduction. By knocking out this gene, researchers can elucidate the role of PPP1R13B in pathophysiological conditions such as cancer, neurodegeneration, and cardiovascular diseases, providing insights into potential therapeutic interventions.
The key function of these cell lines lies in their ability to serve as a controlled experimental platform. The knockout mechanism typically involves CRISPR-Cas9 or similar gene editing technologies that introduce targeted mutations, effectively eliminating the expression of the PPP1R13B gene. This allows for comparative studies between wild-type and knockout cells, enabling the investigation of downstream signaling pathways and cellular responses. By observing how these cells behave in various stimuli or drug treatments, researchers can draw significant conclusions about the gene's biological significance.
From a scientific perspective, PPP1R13B Gene Knockout Cell Lines are invaluable in translational research. Their applications extend across diverse fields, including cancer biology, neurobiology, and developmental studies, making them a versatile tool for both basic and applied sciences. These cell lines can help identify novel biomarkers for disease progression and test the efficacy of new therapeutic compounds.
What sets these knockout cell lines apart from alternatives is their optimized design and validation process, ensuring reproducibility and accuracy in experimental results. Furthermore, our proprietary development methods have increased the reliability of the cell lines, addressing common issues such as low survival rates or inconsistent phenotypic behavior found in competitors’ products.
The value of PPP1R13B Gene Knockout Cell Lines cannot be overstated. Researchers and clinicians will find that these cell lines not only enhance the depth of their investigations but also accelerate the path to therapeutic discoveries. Utilizing these cell lines can significantly enrich scientific data, promoting advances in understanding disease mechanisms and fostering the development of targeted treatments.
Our company prides itself on its dedication to advancing genetic research and providing high-quality biological products. With years of expertise in molecular biology and genetic engineering, we deliver robust solutions tailored to the needs of research and clinical communities.
Please note that all services are for research use only. Not intended for any clinical use.
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