Gene: PPM1L
Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1Lprovided by HGNC
Gene Summary: The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21926 | PPM1L Knockout cell line (HeLa) | Human | PPM1L | 1:3~1:6 | Negative | Online Inquiry |
KO21927 | PPM1L Knockout cell line (HCT 116) | Human | PPM1L | 1:2~1:4 | Negative | Online Inquiry |
KO21928 | PPM1L Knockout cell line (HEK293) | Human | PPM1L | 1:3~1:6 | Negative | Online Inquiry |
PPM1L Gene Knockout Cell Lines are precisely engineered cellular systems designed to facilitate the study of the PPM1L gene and its associated pathways. These knockout models have had the PPM1L gene functionally inactivated, allowing researchers to explore the role of this phosphatase in cellular signaling, stress responses, and developmental biology. By providing an environment where the PPM1L gene is absent, these cell lines enable the investigation of the gene's contributions to processes such as immune response, cell proliferation, and apoptosis.
The key function of PPM1L involves the regulation of various vital substrates, including components of the MAPK and AKT signaling pathways. Through the inactivation of this gene, researchers can observe downstream effects and interactions within these networks, which are crucial for understanding diseases, including cancer and metabolic disorders. This mechanism makes the PPM1L Gene Knockout Cell Lines valuable tools for dissecting the biological roles and potential therapeutic targets associated with PPM1L.
In clinical and research applications, these cell lines are indispensable for drug discovery, functional genomics, and the development of novel therapeutic strategies. They provide a reliable platform for validating gene function and exploring genetic interactions. Unlike competitor offerings, our PPM1L Gene Knockout Cell Lines come with validated backgrounds and comprehensive characterization, ensuring high reproducibility and reliability in experimental outcomes.
Researchers and clinicians will find that utilizing these targeted knockout models facilitates deeper insight into gene functionality, ultimately advancing our understanding of health and disease. The exclusive focus on genetic alterations makes these cell lines a crucial asset for anyone aiming to push the boundaries of biological research. Our company specializes in delivering high-quality biological products backed by rigorous research and expertise, ensuring that our customers have access to the very best tools available on the market.
Please note that all services are for research use only. Not intended for any clinical use.
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