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PPM1H Knockout Cell Lines

Gene: PPM1H

Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1Hprovided by HGNC

Gene Summary: Enables identical protein binding activity and phosphoprotein phosphatase activity. Predicted to be involved in signal transduction. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14948 PPM1H Knockout cell line (HeLa) Human PPM1H 1:3~1:6 Negative Online Inquiry
KO14949 PPM1H Knockout cell line (HCT 116) Human PPM1H 1:2~1:4 Negative Online Inquiry
KO14950 PPM1H Knockout cell line (HEK293) Human PPM1H 1:3~1:6 Negative Online Inquiry
KO14951 PPM1H Knockout cell line (A549) Human PPM1H 1:3~1:4 Negative Online Inquiry

Background

PPM1H Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the in-depth study of the PPM1H gene, which encodes the protein phosphatase Mg2+/Mn2+-dependent 1H. These knockout cell lines have been produced using advanced CRISPR-Cas9 technology, resulting in the precise disruption of the PPM1H gene, leading to a significant loss of its function. By creating these specific knockout models, researchers can effectively elucidate the biological roles of PPM1H, particularly its involvement in regulating signaling pathways and cellular stress responses.

The primary function of the PPM1H gene is to act as a negative regulator of various signaling cascades, including those involved in apoptosis and cell cycle regulation. The knockout of this gene allows for detailed studies into its effects on cell proliferation, survival, and differentiation. Such insights are crucial for understanding the gene's implications in numerous disease pathways, particularly in cancer and neurodegenerative disorders.

The scientific importance of PPM1H Gene Knockout Cell Lines extends to both research and clinical applications. In the laboratory, these models offer invaluable resources for drug discovery, genetic studies, and the development of targeted therapies. Clinically, elucidating the gene's function could lead to innovative strategies for treating diseases where PPM1H dysregulation plays a pivotal role.

One of the key advantages of utilizing PPM1H Gene Knockout Cell Lines over traditional methods is the precision of gene editing, which minimizes off-target effects. This ensures more reliable and reproducible results, enhancing the integrity of scientific findings. Additionally, these cell lines are readily available and easy to culture, allowing researchers and clinicians to quickly integrate them into their existing workflows.

By leveraging the PPM1H Gene Knockout Cell Lines, researchers and clinicians can unlock new avenues of investigation, making it a valuable addition to any developmental or experimental toolkit. At our company, we pride ourselves on providing high-quality biological products backed by cutting-edge technologies and a dedicated team of experts. We understand the critical role that precision and reliability play in scientific research, ensuring that our offerings consistently meet the highest standards of excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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