Gene: PPL
Official Full Name: periplakinprovided by HGNC
Gene Summary: The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35954 | PPL Knockout cell line (HeLa) | Human | PPL | 1:3~1:6 | Negative | Online Inquiry |
KO35955 | PPL Knockout cell line (HCT 116) | Human | PPL | 1:2~1:4 | Negative | Online Inquiry |
KO35956 | PPL Knockout cell line (HEK293) | Human | PPL | 1:3~1:6 | Negative | Online Inquiry |
KO35957 | PPL Knockout cell line (A549) | Human | PPL | 1:3~1:4 | Negative | Online Inquiry |
PPL Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate the study of gene function and disease mechanisms through targeted gene disruption. Utilizing advanced genome-editing technologies such as CRISPR/Cas9, these cell lines enable researchers to create specific gene knockouts, allowing for the observation of phenotypic changes and biological pathways associated with the absent gene.
The key functionality of PPL Gene Knockout Cell Lines lies in their ability to mimic various genetic conditions or diseases, providing a powerful platform for functional genomics studies. By selectively knocking out genes of interest, scientists can elucidate their roles in cellular processes, signaling pathways, and disease progression. These cell lines serve as invaluable tools in drug discovery, toxicology, and the development of targeted therapies, significantly accelerating the pace of biomedical research.
The scientific importance of these cell lines is underscored by their widespread applications in both research and clinical settings. They are instrumental in understanding complex biological processes, validating genetic targets for therapeutic interventions, and assessing the implications of genetic alterations in disease models. Researchers can leverage these models to derive insights into cancer biology, neurodegenerative diseases, and metabolic disorders, among others.
What sets PPL Gene Knockout Cell Lines apart from traditional models is their high specificity, reproducibility, and the ease of use they offer. Unlike older methods that often result in off-target effects or incomplete knockouts, these engineered cells provide reliable data, ultimately leading to more accurate scientific outcomes. Additionally, they come with comprehensive support for customization, allowing researchers to tailor specific lines to their experimental needs.
In today's rapidly evolving research landscape, the value of PPL Gene Knockout Cell Lines becomes evident. They not only enable researchers to advance their hypotheses with confidence but also enhance the potential for breakthroughs in novel therapeutic discoveries. Our company, with its extensive expertise in molecular biology and genetic engineering, is proud to offer these cutting-edge tools, committed to supporting advancements in scientific research and improving human health.
Please note that all services are for research use only. Not intended for any clinical use.
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