Gene: PPAT
Official Full Name: phosphoribosyl pyrophosphate amidotransferaseprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07177 | PPAT Knockout cell line (HeLa) | Human | PPAT | 1:3~1:6 | Negative | Online Inquiry |
KO07178 | PPAT Knockout cell line (HCT 116) | Human | PPAT | 1:2~1:4 | Negative | Online Inquiry |
KO07179 | PPAT Knockout cell line (HEK293) | Human | PPAT | 1:3~1:6 | Negative | Online Inquiry |
PPAT Gene Knockout Cell Lines are specialized cellular models engineered to lack the phosphopantetheine adenylyltransferase (PPAT) gene. This gene plays a crucial role in the biosynthesis of coenzyme A, a fundamental cofactor involved in numerous metabolic pathways, including fatty acid synthesis and the energy metabolism of carbohydrates. By knocking out this critical gene, these cell lines provide invaluable tools for researchers interested in elucidating the biological functions of PPAT and its implications in related metabolic disorders.
The key function of PPAT Gene Knockout Cell Lines lies in their ability to facilitate studies on metabolic dysregulation and its impact on cellular processes. By utilizing these knockout models, researchers can investigate the molecular interactions and metabolic pathways that are disrupted in the absence of PPAT. This information is essential for understanding disease mechanisms and identifying potential therapeutic targets in conditions such as obesity, diabetes, and other metabolic syndromes.
In clinical and research settings, these cell lines have significant applications, including drug discovery and the development of gene therapies. The PPAT knockout model allows for the assessment of drug efficacy against metabolic diseases, enabling researchers to screen potential therapeutics in a controlled environment where the PPAT pathway is specifically inactivated.
One key advantage of PPAT Gene Knockout Cell Lines over traditional models is their specificity and precision. They provide a clean genetic background that eliminates the confounding effects of endogenous PPAT activity, allowing for clearer interpretation of experimental results. Compared to similar products, these knockout cell lines are characterized by rigorous validation processes, ensuring their reliability for high-stakes research.
The value of PPAT Gene Knockout Cell Lines to researchers and clinicians is profound; they offer a unique opportunity to delve into the complexities of metabolic regulation, potentially leading to groundbreaking discoveries and advancements in therapeutic approaches. Furthermore, our company's expertise in cellular model development ensures that each product meets the highest standards of quality and performance, making us a trusted partner in your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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