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POU6F1 Knockout Cell Lines

Gene: POU6F1

Official Full Name: POU class 6 homeobox 1provided by HGNC

Gene Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in actin cytoskeleton and nuclear body. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03497 POU6F1 Knockout cell line (HeLa) Human POU6F1 1:3~1:6 Negative Online Inquiry
KO03498 POU6F1 Knockout cell line (HCT 116) Human POU6F1 1:2~1:4 Negative Online Inquiry
KO03499 POU6F1 Knockout cell line (HEK293) Human POU6F1 1:3~1:6 Negative Online Inquiry

Background

POU6F1 Gene Knockout Cell Lines are meticulously engineered cellular systems characterized by the targeted disruption of the POU6F1 gene, which encodes a transcription factor crucial for neural development and maintenance. These knockout cell lines serve as vital experimental tools in understanding the functional roles of POU6F1 within cellular processes, especially in the context of neurogenesis and neurological disorders. By employing CRISPR-Cas9 gene editing technology, the knockout of POU6F1 allows researchers to investigate the consequences of gene loss on cell behavior, differentiation, and signaling pathways.

The primary mechanism through which the POU6F1 gene knockout operates is by eliminating the expression of the POU6F1 protein, which acts as a transcriptional regulator influencing gene expression patterns that govern cell fate decisions in the nervous system. This reduction in transcriptional activity leads to observable phenotypic changes, making these cell lines invaluable for elucidating the specific pathways and molecular interactions affected by POU6F1.

In the realm of scientific research, these knockout cell lines present groundbreaking opportunities for studying developmental biology, neurobiology, and regenerative medicine. They facilitate preclinical models in evaluating potential therapeutic approaches for neurodegenerative diseases, psychiatric disorders, and developmental anomalies. Furthermore, by providing a controlled environment to dissect gene function and cellular dynamics, these cell lines can significantly advance our understanding of complex biological processes.

What sets POU6F1 Gene Knockout Cell Lines apart from other genetic models is the purity and consistency of gene editing achieved through our advanced CRISPR methodologies. These cell lines undergo rigorous validation to ensure high specificity and reproducibility, minimizing the variability often seen in alternative models. Researchers will appreciate the ease of use, comprehensive documentation, and robust technical support encapsulating our commitment to facilitating high-quality research.

In summary, POU6F1 Gene Knockout Cell Lines represent a critical resource for scientists and clinicians aiming to unravel the underlying mechanisms of neurological functions and disorders. Supported by our company's extensive expertise in genetic engineering and commitment to biotechnological advancement, these products are designed to empower your research initiatives and contribute to meaningful discoveries in the field of cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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